F
Fred S. Apple
Researcher at University of Minnesota
Publications - 424
Citations - 37563
Fred S. Apple is an academic researcher from University of Minnesota. The author has contributed to research in topics: Myocardial infarction & Troponin I. The author has an hindex of 85, co-authored 397 publications receiving 35005 citations. Previous affiliations of Fred S. Apple include Karolinska Institutet & Washington University in St. Louis.
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Journal ArticleDOI
Universal definition of myocardial infarction.
Kristian Thygesen,Joseph S. Alpert,Harvey D. White,Allan S. Jaffe,Fred S. Apple,Marcello Galvani,Hugo A. Katus,L. Kristin Newby,Jan Ravkilde,Bernard R. Chaitman,Peter Clemmensen,Mikael Dellborg,Hanoch Hod,Pekka Porela,Richard Underwood,Jeroen J. Bax,George A. Beller,Robert O. Bonow,Ernst E. van der Wall,Jean-Pierre Bassand,William Wijns,T. Bruce Ferguson,Philippe Gabriel Steg,Barry F. Uretsky,David O. Williams,Paul W. Armstrong,Elliott M. Antman,Keith A.A. Fox,Christian W. Hamm,E. Magnus Ohman,Maarten L. Simoons,Philip A. Poole-Wilson,Enrique P. Gurfinkel,José-Luis López-Sendón,Prem Pais,Shanti Mendis,Jun-Ren Zhu,Lars Wallentin,Francisco Fernández-Avilés,Kim Fox,Alexander Parkhomenko,Silvia G. Priori,Michal Tendera,Liisa-Maria Voipio-Pulkki,Alec Vahanian,A. John Camm,Raffaele De Caterina,Veronica Dean,Kenneth Dickstein,Gerasimos Filippatos,Christian Funck-Brentano,Irene Hellemans,Steen Dalby Kristensen,Keith McGregor,Udo Sechtem,Sigmund Silber,Petr Widimsky,José Luis Zamorano,João Morais,Sorin J. Brener,Robert A. Harrington,David A. Morrow,Michael J. Lim,Marco A. Martinez-Rios,Steve Steinhubl,Glen N. Levine,W. Brian Gibler,David C. Goff,Marco Tubaro,Darek Dudek,Nawwar Al-Attar +70 more
TL;DR: Information on myocardial infarction attack rates can provide useful data regarding the burden of coronary artery disease within and across populations, especially if standardized data are collected in a manner that demonstrates the distinction between incident and recurrent events.
Journal ArticleDOI
Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
Joseph S. Alpert,Elliott M. Antman,Fred S. Apple,Paul W. Armstrong,J. P. Bassand,A. B. De Luna,George A. Beller,Günter Breithardt,Bernard R. Chaitman,Peter Clemmensen,Erling Falk,Michael C. Fishbein,Marcello Galvani,A Jr Garson,Cindy L. Grines,Christian W. Hamm,B. Nauheim,Uta C. Hoppe,Allan S. Jaffe,Hugo A. Katus,J. Kjeksus,Werner Klein,P. Klootwijk,C. Lenfant,Daniel Levy,R. I. Levy,Russell V. Luepker,F. Marcus,Ulf Näslund,Magnus Ohman,O. Pahlm,P. A. Poole-Wilson,R. Popp,Kalevi Pyörälä,Jan Ravkilde,N. Rehnquist,W. Roberts,Robert Roberts,J. Roelandt,Lars Rydén,Susana Sans,M. L. Simoons,Kristian Thygesen,Hugh Tunstall-Pedoe,Richard Underwood,Barry F. Uretsky,F. Van de Werf,L. M. Voipio-Pulkki,Galen S. Wagner,Lars Wallentin,William Wijns,David R. Wood +51 more
TL;DR: Biochemical markers of myocardial necrosis may have normalized, depending on the length of time that has passed since the infarct developed, and one of the following criteria satisfies the diagnosis for established MI: development of new pathologic Q waves on serial ECGs.
Journal ArticleDOI
Cardiac troponin I. A marker with high specificity for cardiac injury.
Jesse E. Adams,Geza S. Bodor,Victor G. Dávila-Román,James A. Delmez,Fred S. Apple,Jack H. Ladenson,Allan S. Jaffe +6 more
TL;DR: Measurement of cardiac troponin I (cTnI) has sufficient specificity to clarify the etiology of MBCK elevations in patients with acute or chronic skeletal muscle disease or renal failure, and Elevations of cTNI are highly specific for myocardial injury.
Journal ArticleDOI
Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery
Jeffrey L. Carson,Michael L. Terrin,Helaine Noveck,David W. Sanders,Bernard R. Chaitman,George G. Rhoads,George J. Nemo,Karen Dragert,Lauren A Beaupre,Kevin A. Hildebrand,William Macaulay,Courtland Lewis,Donald Richard Cook,Gwendolyn Dobbin,Khwaja J. Zakriya,Fred S. Apple,Rebecca A. Horney,Jay Magaziner +17 more
TL;DR: A liberal transfusion strategy, as compared with a restrictive strategy, did not reduce rates of death or inability to walk independently on 60-day follow-up or reduce in-hospital morbidity in elderly patients at high cardiovascular risk.
Journal ArticleDOI
Ferritin: a cytoprotective antioxidant strategem of endothelium.
György Balla,Harry S. Jacob,József Balla,Murray D. Rosenberg,Karl A. Nath,Fred S. Apple,John W. Eaton,Gregory M. Vercellotti +7 more
TL;DR: It is concluded that endothelium and perhaps other cell types may be protected from oxidant damage through the iron sequestrant, ferritin.