Gregory R. Kirk

TL;DR: Reliability and similarity of resting-state functional connectivity can be greatly improved by increasing the scan lengths, and that both the increase in the number of volumes as well as the length of time over which these volumes was acquired drove this increase in reliability.

TL;DR: Resting-state fMRI has been demonstrated to have moderate to high reliability and produces consistent patterns of connectivity across a wide variety of subjects, sites, and scanners but there is no one agreed upon method to acquire rs-fMRI data.

TL;DR: Based on known nonneuronal mechanisms by which cardiac pulsation and respiration can lead to MRI signal changes, and the observation that the physiological noise itself is highly stable within individuals, removal of this noise will likely increase the validity of measured connectivity differences and lead to better estimates of average or group maps of connectivity.

TL;DR: Brain cortical thickness was compared between age- and education-matched groups of older HIV-seropositive subjects on HAART who had detectable and undetectable PBMC HIV DNA and revealed highly significant cortical thinning associated with detectable HIV DNA.

TL;DR: Inability to clear peripheral blood of HIV DNA is associated with regional brain atrophy in well-controlled HIV infection, supporting the involvement of peripheral viral reservoirs in the neuropathogenesis of persistent HIV-related neurocognitive disorders.