Institution
Huntington Medical Research Institutes
Nonprofit•Pasadena, California, United States•
About: Huntington Medical Research Institutes is a nonprofit organization based out in Pasadena, California, United States. It is known for research contribution in the topics: Magnetic resonance imaging & Myocardial infarction. The organization has 433 authors who have published 682 publications receiving 29631 citations.
Topics: Magnetic resonance imaging, Myocardial infarction, Glutamine, Nitric oxide, Hyperpolarization (physics)
Papers published on a yearly basis
Papers
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TL;DR: In patients with HBeAg-positive chronic hepatitis B, 48 weeks of 10 mg or 30 mg of adefovir dipivoxil per day resulted in histologic liver improvement, reduced serum HBV DNA and alanine aminotransferase levels, and increased the rates of H beAg seroconversion.
Abstract: Background In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains. Methods We randomly assigned 515 patients with chronic hepatitis B who were positive for hepatitis B e antigen (HBeAg) to receive 10 mg of adefovir dipivoxil (172 patients), 30 mg of adefovir dipivoxil (173), or placebo (170) daily for 48 weeks. The primary end point was histologic improvement in the 10-mg group as compared with the placebo group. Results After 48 weeks of treatment, significantly more patients who received 10 mg or 30 mg of adefovir dipivoxil per day than who received placebo had histologic improvement (53 percent [P<0.001], 59 percent [P<0.001], and 25 percent, respectively), a reduction in serum HBV DNA levels (by a median of 3.52 [P<0.001], 4.76 [P<0.001], and 0.55 log copies per milliliter, respectively), undetectable levels (fewer than 400 copies per milliliter) of serum HBV DNA (21 percent [P<0.001], 39 percent [P<0....
1,321 citations
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TL;DR: Evidence suggests that NAA is a direct precursor for the enzymatic synthesis of the neuron specific dipeptides N-acetylaspartylglutamate, the most concentrated neuropeptide in the human brain, and it is proposed that N AA may also be involved in brain nitrogen balance.
1,190 citations
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TL;DR: The suitability of spheroids as an in vitro platform for testing drug delivery systems is examined and the assay techniques required for the characterization of drug delivery and efficacy in sp Heroids are discussed.
936 citations
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TL;DR: Neuroimaging and cerebrospinal fluid analyses in humans reveal that loss of blood–brain barrier integrity and brain capillary pericyte damage are early biomarkers of cognitive impairment that occur independently of changes in amyloid-β and tau.
Abstract: Vascular contributions to cognitive impairment are increasingly recognized1-5 as shown by neuropathological6,7, neuroimaging4,8-11, and cerebrospinal fluid biomarker4,12 studies. Moreover, small vessel disease of the brain has been estimated to contribute to approximately 50% of all dementias worldwide, including those caused by Alzheimer's disease (AD)3,4,13. Vascular changes in AD have been typically attributed to the vasoactive and/or vasculotoxic effects of amyloid-β (Aβ)3,11,14, and more recently tau15. Animal studies suggest that Aβ and tau lead to blood vessel abnormalities and blood-brain barrier (BBB) breakdown14-16. Although neurovascular dysfunction3,11 and BBB breakdown develop early in AD1,4,5,8-10,12,13, how they relate to changes in the AD classical biomarkers Aβ and tau, which also develop before dementia17, remains unknown. To address this question, we studied brain capillary damage using a novel cerebrospinal fluid biomarker of BBB-associated capillary mural cell pericyte, soluble platelet-derived growth factor receptor-β8,18, and regional BBB permeability using dynamic contrast-enhanced magnetic resonance imaging8-10. Our data show that individuals with early cognitive dysfunction develop brain capillary damage and BBB breakdown in the hippocampus irrespective of Alzheimer's Aβ and/or tau biomarker changes, suggesting that BBB breakdown is an early biomarker of human cognitive dysfunction independent of Aβ and tau.
836 citations
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TL;DR: The first study of absolute metabolite concentrations and T1‐and T2‐relaxation as a function of age is presented, expected to be of particular value in diagnosis and monitoring of pathology in infants, since metabolite ratios are often misleading.
Abstract: Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations. The current report presents the first study of absolute metabolite concentrations and T1- and T2- relaxation as a function of age. Myo-inositol was found dominating the spectra at birth (12 mmoles/kg), while choline is responsible for the strongest peak in older infants (2.5 mmoles/kg). Creatine and N-acetyl groups are at significantly lower concentrations in the neonate than in the adult (Cr: 6, NA: 5 mmoles/kg). NA and Cr are determined by gestational age, whereas the concentration of ml correlates best with postnatal age. Quantitative 1H MRS is expected to be of particular value in diagnosis and monitoring of pathology in infants, since metabolite ratios are often misleading.
674 citations
Authors
Showing all 434 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert A. Kloner | 111 | 780 | 53767 |
Steven B. Abramson | 87 | 285 | 27621 |
Rolf Gruetter | 78 | 436 | 22345 |
Linda R. Petzold | 69 | 318 | 21391 |
Myron J. Tong | 65 | 234 | 15434 |
Shahbudin H. Rahimtoola | 62 | 314 | 17844 |
John C. Chatham | 59 | 182 | 13692 |
Thomas Ernst | 57 | 179 | 12778 |
Roland Kreis | 57 | 171 | 11902 |
Eduard Y. Chekmenev | 50 | 179 | 7170 |
Sharon L. Hale | 48 | 142 | 7362 |
Adam N. Mamelak | 47 | 158 | 7548 |
Brian D. Ross | 47 | 148 | 9953 |
William G. Bradley | 47 | 144 | 8931 |
Stefan Bluml | 42 | 131 | 5224 |