G
Gretchen M. Lentz
Researcher at University of Washington
Publications - 53
Citations - 3060
Gretchen M. Lentz is an academic researcher from University of Washington. The author has contributed to research in topics: Cryopreservation & T cell. The author has an hindex of 27, co-authored 52 publications receiving 2893 citations. Previous affiliations of Gretchen M. Lentz include University of Washington Medical Center.
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Journal ArticleDOI
A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract.
Laura Pattacini,Amanda S. Woodward Davis,Julie Czartoski,Florian Mair,Scott R. Presnell,Sean M. Hughes,Ollivier Hyrien,Gretchen M. Lentz,Anna C Kirby,Michael F. Fialkow,Florian Hladik,Martin Prlic,Jennifer M. Lund,Jennifer M. Lund +13 more
TL;DR: The immune system of the cervicovaginal tract must balance immunosurveillance and active immunity against pathogens with maintenance of tolerance to resident microbiota and to fetal and partner antigens for reproductive purposes to highlight the specialized nature of immunity within the CVT.
Journal ArticleDOI
The human memory T cell compartment changes across tissues of the female reproductive tract.
Amanda S. Woodward Davis,Sarah C. Vick,Laura Pattacini,Valentin Voillet,Sean M. Hughes,Gretchen M. Lentz,Anna C Kirby,Michael F. Fialkow,Raphael Gottardo,Florian Hladik,Florian Hladik,Jennifer M. Lund,Jennifer M. Lund,Martin Prlic,Martin Prlic +14 more
TL;DR: In this paper, the authors examined CD4 T cells in donor-matched vaginal, ecto-and endocervical tissues, which differ in mucosal structure and exposure to external environmental stimuli.
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Mechanisms of Endogenous HIV-1 Reactivation by Endocervical Epithelial Cells.
Germán G. Gornalusse,Rogelio Valdez,Gabriella Fenkart,Lucia Vojtech,Lamar M. Fleming,Urvashi Pandey,Sean M. Hughes,Claire N. Levy,Erin J. dela Cruz,Erin J. dela Cruz,Fernanda Calienes,Anna C Kirby,Michael F. Fialkow,Gretchen M. Lentz,Jessica Wagoner,Lichen Jing,David M. Koelle,Stephen J. Polyak,David N. Fredricks,David N. Fredricks,M. Juliana McElrath,M. Juliana McElrath,Anna Wald,Florian Hladik,Florian Hladik +24 more
TL;DR: HIV-1 reactivation in the female genital tract is studied to find that columnar epithelial cells lining the endocervix, the lower part of the uterus, are particularly effective in reactivating HIV-1 from infected T cells, which may contribute to viral blips during ART or rebound following ART interruption.
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Determination of the Membrane Permeability to Water of Human Vaginal Mucosal Immune Cells at Subzero Temperatures Using Differential Scanning Calorimetry
Zhiquan Shu,Sean M. Hughes,Cifeng Fang,Zhiyuan Hou,Gang Zhao,Michael F. Fialkow,Gretchen M. Lentz,Florian Hladik,Dayong Gao +8 more
TL;DR: In this study, the cell membrane permeabilities to water at subzero temperatures of human vaginal mucosal T cells and macrophages were measured using the differential scanning calorimetry method proposed by Devireddy et al. in 1998.