M
M. Juliana McElrath
Researcher at Fred Hutchinson Cancer Research Center
Publications - 328
Citations - 26267
M. Juliana McElrath is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Vaccination & HIV vaccine. The author has an hindex of 72, co-authored 292 publications receiving 21165 citations. Previous affiliations of M. Juliana McElrath include HIV Vaccine Trials Network & University of Washington.
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Journal ArticleDOI
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Greg Finak,Andrew McDavid,Masanao Yajima,Jingyuan Deng,Vivian H. Gersuk,Alex K. Shalek,Chloe K. Slichter,Hannah W. Miller,M. Juliana McElrath,Martin Prlic,Peter S. Linsley,Raphael Gottardo +11 more
TL;DR: This work argues that the cellular detection rate, the fraction of genes expressed in a cell, should be adjusted for as a source of nuisance variation and provides gene set enrichment analysis tailored to single-cell data.
Journal ArticleDOI
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial.
Susan Buchbinder,Devan V. Mehrotra,Ann Duerr,Daniel W. Fitzgerald,Robin Mogg,David Li,Peter B. Gilbert,Javier R. Lama,Michael Marmor,Carlos del Rio,M. Juliana McElrath,Danilo R. Casimiro,Keith Gottesdiener,Chodakewitz Jeffrey A,Lawrence Corey,Michael N. Robertson +15 more
TL;DR: This cell-mediated immunity vaccine did not prevent HIV-1 infection or reduce early viral level and Mechanisms for insufficient efficacy of the vaccine and the increased HIV- 1 infection rates in subgroups of vaccine recipients are being explored.
Journal ArticleDOI
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
Barton F. Haynes,Peter B. Gilbert,M. Juliana McElrath,Susan Zolla-Pazner,Georgia D. Tomaras,S. Munir Alam,David T. Evans,David C. Montefiori,Chitraporn Karnasuta,Ruengpueng Sutthent,Hua-Xin Liao,Anthony L. DeVico,George K. Lewis,Constance Williams,Abraham Pinter,Youyi Fong,Holly Janes,Allan C. deCamp,Yunda Huang,Mangala Rao,Erik Billings,Nicos Karasavvas,Merlin L. Robb,Viseth Ngauy,Mark de Souza,Robert Paris,Guido Ferrari,Robert T. Bailer,Kelly A. Soderberg,Charla Andrews,Phillip W. Berman,Nicole Frahm,Stephen C. De Rosa,Michael D. Alpert,Nicole L. Yates,Xiaoying Shen,Richard A. Koup,Punnee Pitisuttithum,Jaranit Kaewkungwal,Sorachai Nitayaphan,Supachai Rerks-Ngarm,Nelson L. Michael,Jerome H. Kim +42 more
TL;DR: V vaccines that are designed to induce higher levels of V1V2 antibodies and lower levels of Env-specific IgA antibodies than are induced by the RV144 vaccine may have improved efficacy against HIV-1 infection.
Journal ArticleDOI
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis
M. Juliana McElrath,M. Juliana McElrath,Stephen C. De Rosa,Stephen C. De Rosa,Zoe Moodie,Sheri Dubey,Lisa Kierstead,Holly Janes,Olivier D. Defawe,Donald K. Carter,John Hural,Rama Akondy,Susan Buchbinder,Michael N. Robertson,Devan V. Mehrotra,Steven G. Self,Steven G. Self,Lawrence Corey,Lawrence Corey,John W. Shiver,Danilo R. Casimiro +20 more
TL;DR: Consistent with previous trials, the MRKAd5 HIV-1 gag/pol/nef vaccine was highly immunogenic for inducing HIV-specific CD8+ T cells and suggest that future candidate vaccines have to elicit responses that either exceed in magnitude or differ in breadth or function from those recorded in this trial.
Posted ContentDOI
MAST: A flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA-seq data
Greg Finak,Andrew McDavid,Masanao Yajima,Jingyuan Deng,Vivian H. Gersuk,Alex K. Shalek,Chloe K. Slichter,Hannah W. Miller,M. Juliana McElrath,Martin Prlic,Peter S. Linsley,Raphael Gottardo +11 more
TL;DR: A new methodology to analyze single-cell transcriptomic data is presented that models this bimodality within a coherent generalized linear modeling framework, and the cellular detection rate, the fraction of genes turned on in a cell, is introduced.