G
Gretchen M. Thomsen
Researcher at Cedars-Sinai Medical Center
Publications - 24
Citations - 616
Gretchen M. Thomsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Traumatic brain injury & Amyotrophic lateral sclerosis. The author has an hindex of 10, co-authored 24 publications receiving 500 citations. Previous affiliations of Gretchen M. Thomsen include Columbia University & University of California, Los Angeles.
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Journal ArticleDOI
The past, present and future of stem cell clinical trials for ALS
TL;DR: A critical review of current clinical trials using either mesenchymal or neural stem cells to treat ALS patients is provided and mechanisms of action, validity of conclusions and rationale for advancing stem cell treatment strategies for this devastating disorder are evaluated.
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Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex
Gretchen M. Thomsen,Genevieve Gowing,Jessica Latter,Maximus Chen,Jean-Philippe Vit,Kevin Staggenborg,Pablo Avalos,Mor Alkaslasi,Laura Ferraiuolo,Shibi Likhite,Brian K. Kaspar,Clive N. Svendsen +11 more
TL;DR: It is shown that, in the SOD1G93A rat model of ALS, spinal motor neuron loss occurs presymptomatically and before degeneration of ventral root axons and denervation of NMJs, which suggests an early dysfunction and thus an important role of the upper motor neuron in this animal model ofALS and perhaps patients with the disease.
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Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis.
Gretchen M. Thomsen,Pablo Avalos,Annie A. Ma,Mor Alkaslasi,Noell Cho,Livia Wyss,Jean-Philippe Vit,Marlesa Godoy,Patrick Suezaki,Oksana Shelest,Krystof S. Bankiewicz,Clive N. Svendsen +11 more
TL;DR: Introducing cortical astrocytes releasing GDNF represents a novel promising approach to treating ALS, and protected motor neurons, delayed disease pathology and extended survival of the animals.
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Early propranolol after traumatic brain injury is associated with lower mortality.
Ara Ko,Megan Y. Harada,Galinos Barmparas,Gretchen M. Thomsen,Rodrigo F. Alban,Matthew B. Bloom,Rex Chung,Nicolas Melo,Daniel R. Margulies,Eric J. Ley +9 more
TL;DR: After adjusting for predictors of mortality, early administration of propranolol after TBI was associated with improved survival and future studies are needed to identify additional benefits and optimal dosing regimens.
Journal ArticleDOI
Dopamine neuron dependent behaviors mediated by glutamate cotransmission.
Susana Mingote,Nao Chuhma,Abigail Kalmbach,Gretchen M. Thomsen,Yvonne Wang,Andra Mihali,Caroline E. Sferrazza,Ilana Zucker-Scharff,Anna-Claire Siena,Martha G. Welch,José E. Lizardi-Ortiz,David Sulzer,Holly Moore,Inna Gaisler-Salomon,Inna Gaisler-Salomon,Stephen Rayport +15 more
TL;DR: A reduction in dopamine neuron glutamate cotransmission appears to mediate significant components of the GLS1 HET schizophrenia resilience phenotype, and glutamate cOTransmissions appears to be important in attribution of motivational salience.