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Guang Chen

Researcher at Tianjin University

Publications -  304
Citations -  20345

Guang Chen is an academic researcher from Tianjin University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 63, co-authored 227 publications receiving 16598 citations. Previous affiliations of Guang Chen include National Institutes of Health & Peking Union Medical College.

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Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

TL;DR: Subanesthetic doses of ketamine treatment caused acute and sustained antidepressant-like effects and at these doses, ketamine did not impair fear memory retention and NMDA antagonists might exert rapid antidepressant- like effects by enhancing AMPA relative to NMDA throughput in critical neuronal circuits.
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Enhancement of hippocampal neurogenesis by lithium.

TL;DR: The results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long‐term treatment of other neuropsychiatric disorders.
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Lithium-induced increase in human brain grey matter

TL;DR: Three-dimensional magnetic resonance imaging and brain segmentation were used to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder.
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The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

TL;DR: These novel findings represent the first report of medication‐induced increases in CNS bcl‐2 levels and may have implications not only for mood disorders, but also for long‐term treatment of various neurodegenerative disorders.