Guanghao Zhu

TL;DR: All information and knowledge presented here are very helpful for understanding the structural features and inhibitory mechanisms of SARS‐CoV‐2 3CLpro inhibitors, which offers new insights or inspiration to medicinal chemists for designing and developing more efficacious 3CL Pro inhibitors as novel anti‐coronavirus agents.

TL;DR: Collectively, POL and its major component Myr can ameliorate NASH via down-regulating and inhibiting PTGS2, suggesting that POL and Myr can be developed as novel medicines for treating NASH.

TL;DR: This study reveals the key anti-obesity constituents in AGE and elucidates their inhibitory mechanisms against hPL, which offers convincing evidence to support the anti-OBesity and lipid-lowering effects of this edible herb.

TL;DR: The inhibitory effects of Shuang-huang-lian injections and its major constituents in the herbal medicine, including baicalein, baicalin, and hyperoside, on bilirubin glucuroBBREVInidation were investigated and suggested that SHL, BAI, BA, and HYP significantly inhibited hUGT1A1-mediated bilirUBin glucuronidation via a mixed-type inhibition.

TL;DR: The key constituents in GBL responsible for hUGT1A1 inhibition are uncovered and their inhibitory mechanisms are deciphered, which will be very helpful for guiding the rational use of GBL-related herbal products in clinical settings.