Guang-Bo Ge

TL;DR: The information presented here will help pharmacologists explore the relevance of CES to human diseases or to assign the contribution of certain CES in xenobiotic metabolism, and facilitate medicinal chemistry efforts to design prodrugs activated by a given CES isoform, or to develop potent and selective modulators of CES for potential biomedical applications.

TL;DR: The de novo assembly of Taxus mairei transcriptome using Illumina paired-end sequencing technology provides the most comprehensive sequence resource available for Taxus study and will help define mechanisms of tissue specific functions and secondary metabolism in non-model plant organisms.

TL;DR: A two-photon excited ratiometric fluorescent probe NCMN has been developed and well-characterized for sensitive and selective detection of CYP1A, which holds great promise for bioimaging of endogenous CYp1A in living cells and for further investigation on CYP 1A associated biological functions in complex biological systems.

TL;DR: BnXPI was successfully used to monitor CYP2J2 activity in real-time for various living systems including cells, tumor tissues, and tumor-bearing animals and displayed the best combination of specificity, sensitivity and applicability for detecting CYP 2J2 in vitro and in vivo.

TL;DR: A two-photon ratiometric fluorescent probe NCEN designed and developed for highly selective and sensitive sensing of human carboxylesterase 2 (hCE2) based on the catalytic properties and substrate preference showed great promise for applications in bioimaging of endogenous h CE2 in living cells and in exploring the biological functions of hCE2 in complex biological systems.