G
Guha Asthagiri Arunkumar
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 15
Citations - 3113
Guha Asthagiri Arunkumar is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Virus & Hemagglutinin (influenza). The author has an hindex of 9, co-authored 14 publications receiving 2083 citations.
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A serological assay to detect SARS-CoV-2 seroconversion in humans.
Fatima Amanat,Daniel Stadlbauer,Shirin Strohmeier,Shirin Strohmeier,Thi H. O. Nguyen,Veronika Chromikova,Meagan McMahon,Kaijun Jiang,Guha Asthagiri Arunkumar,Denise Jurczyszak,Jose Polanco,Maria Bermudez-Gonzalez,Giulio Kleiner,Teresa Aydillo,Lisa Miorin,Daniel S. Fierer,Luz Amarilis Lugo,Erna Milunka Kojic,Jonathan Stoever,Sean T. H. Liu,Charlotte Cunningham-Rundles,Philip L. Felgner,Thomas M. Moran,Adolfo García-Sastre,Daniel Caplivski,Allen C. Cheng,Katherine Kedzierska,Olli Vapalahti,Jussi Hepojoki,Jussi Hepojoki,Viviana Simon,Florian Krammer +31 more
TL;DR: A serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters and can be adjusted to detect different antibody types in serum and plasma.
Journal ArticleDOI
SARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup.
Daniel Stadlbauer,Fatima Amanat,Veronika Chromikova,Kaijun Jiang,Shirin Strohmeier,Shirin Strohmeier,Guha Asthagiri Arunkumar,Jessica Tan,Disha Bhavsar,Christina Capuano,Ericka Kirkpatrick,Philip Meade,Ruhi Nichalle Brito,Catherine Teo,Meagan McMahon,Viviana Simon,Florian Krammer +16 more
TL;DR: A detailed protocol for expression of antigens derived from the spike protein of SARS‐CoV‐2 that can serve as a substrate for immunological assays, as well as a two‐stage serological enzyme‐linked immunosorbent assay (ELISA) can be used for research studies and for testing in clinical laboratories.
Posted ContentDOI
A serological assay to detect SARS-CoV-2 seroconversion in humans
Fatima Amanat,Daniel Stadlbauer,Shirin Strohmeier,Shirin Strohmeier,Thi H. O. Nguyen,Veronika Chromikova,Meagan McMahon,Kaijun Jiang,Guha Asthagiri Arunkumar,Denise Jurczyszak,Jose Polanco,Maria Bermudez-Gonzalez,Giulio Kleiner,Teresa Aydillo,Lisa Miorin,Daniel S. Fierer,Luz Amarilis Lugo,Erna Milunka Kojic,Jonathan Stoever,Sean T. H. Liu,Charlotte Cunningham-Rundles,Philip L. Felgner,Thomas M. Moran,Adolfo García-Sastre,Daniel Caplivski,Allen C. Cheng,Katherine Kedzierska,Olli Vapalahti,Jussi Hepojoki,Jussi Hepojoki,Viviana Simon,Florian Krammer +31 more
TL;DR: Serological assays are of critical importance to determine seroprevalence in a given population, define previous exposure and identify highly reactive human donors for the generation of convalescent serum as therapeutic.
Journal ArticleDOI
Repeated cross-sectional sero-monitoring of SARS-CoV-2 in New York City.
Daniel Stadlbauer,Jessica Tan,Kaijun Jiang,Matthew M. Hernandez,Shelcie Fabre,Fatima Amanat,Catherine Teo,Guha Asthagiri Arunkumar,Meagan McMahon,Christina Capuano,Kathryn Twyman,Jeffrey S. Jhang,Michael D. Nowak,Viviana Simon,Emilia Mia Sordillo,Harm van Bakel,Florian Krammer +16 more
TL;DR: The data suggest that SARS-CoV-2 was introduced in New York City earlier than previously documented and describe the dynamics of seroconversion over the full course of the first wave of the pandemic in a major metropolitan area.
Journal ArticleDOI
Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice.
Guha Asthagiri Arunkumar,Andriani Ioannou,Teddy John Wohlbold,Philip Meade,Sadaf Aslam,Fatima Amanat,Juan Ayllon,Adolfo García-Sastre,Florian Krammer +8 more
TL;DR: The characterization of 22 broadly cross-reactive, nonneutralizing antibodies specific for influenza B virus hemagglutinin will inform the design of urgently needed vaccines that could induce broad protection against influenza B viruses.