Guido Lucarelli

TL;DR: It is concluded that for patients under 16 years of age, transplantation of bone marrow from an HLA-identical donor offers a high probability of complication-free survival, particularly if they do not have hepatomegaly or portal fibrosis.

TL;DR: The hepatic iron concentration is a reliable indicator of total body iron stores in patients with thalassemia major and in patientsWith transfusion-related iron overload, repeated determinations of the hepaticIron concentration can provide a quantitative means of measuring the long-term iron balance.

TL;DR: In this article, the role of iron overload in the natural history of liver fibrosis was identified, and the risk for fibrosis progression correlated to medium hepatic iron content (hazard rate, 1.9; 95% confidence interval [CI], 0.74-5.5).

TL;DR: 30 patients with homozygous beta-thalassaemia received allogeneic marrow transplants following busulphan (Bu) and cyclophosphamide (Cy) and post-transplant immunosuppression was with methotrexate (MTX) or MTX and Cy.

TL;DR: The high probability of cure with little early or late morbidity and mortality suggests that patients with class 1 thalassemia who have HLA-identical donors available should be treated by bone marrow transplantation.