G
Gunjan Saxena
Researcher at Central Drug Research Institute
Publications - 14
Citations - 735
Gunjan Saxena is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Morris water navigation task & Yield (chemistry). The author has an hindex of 12, co-authored 14 publications receiving 676 citations.
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Journal ArticleDOI
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice
TL;DR: Results indicate that tacrine and donepezil, beside inhibition of acetylcholinesterase, may also suppress oxidative stress.
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Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice.
Gunjan Saxena,Sheelendra Pratap Singh,Raghvendra Pal,Stayawan Singh,Ram Pratap,Chandishwar Nath +5 more
TL;DR: The study demonstrated that gugulipid has significant protective affect against streptozotocin-induced memory deficits model of dementia that can be attributed to anti-oxidant and anti-AChE activity of gugULipid.
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Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
Shailendra S. Chaudhaery,Kuldeep K. Roy,Neeraj Shakya,Gunjan Saxena,Shreesh Raj Sammi,Aamir Nazir,Chandishwar Nath,Anil K. Saxena +7 more
TL;DR: The synthesis and pharmacological evaluation of nine carbamates against three diverse assay systems led to the discovery of orally active novel AChE inhibitors which improved scopolamine-induce cognition impairment in Swiss male mice.
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Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity ☆
TL;DR: It is demonstrated that the clinically used anti-dementic drugs are effective in OKA induced free radical generation and memory impairment in rats, appearing as a useful test model to screen anti-Dementia drugs.
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ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
TL;DR: The results indicate that instead of muscarinic receptors nicotinic receptors may be involved in neuroprotection by maintaining mitochondria functions by maintaining mitochondrial functions.