Günter A.J. Riegger

TL;DR: The findings suggest thatleft ventricular hypertrophy is partially determined by genetic disposition and identifies the DD genotype of ACE as a potential genetic marker associated with an elevated risk of left ventricularhypertrophy in middle-aged men.

TL;DR: It is shown, by using variance component analysis and incorporating risk factors, that risk of myocardial infarction maps to a single region on chromosome 14 with a significant lod score of 3.9, providing evidence of a principal MI locus.

TL;DR: There is a sexual dimorphism of prorenin levels in humans, suggesting that sex hormones affect the regulation of the renin gene, and data confirm previous reports of elevated prorenIn levels in diabetics and older subjects, as well as of lower than normal levels in subjects with hypertension in smaller populations.

TL;DR: In rats, a toxic dosage of isoproterenol caused characteristic myocardial damage that subsequently resulted in mild heart failure that seems to require functional integrity of the renin-angiotensin system.

TL;DR: Compared with phorbol ester stimulation, angiotensin II effects on PKC translocation were significantly less pronounced and required a more prolonged stimulation, and the pathways of angiotsin signal transduction, protein kinase C (PKC)-epsilon as well as cardiac c-fos and c-jun mRNA levels were analyzed.