G
Guo-Chang Fan
Researcher at University of Cincinnati Academic Health Center
Publications - 136
Citations - 9112
Guo-Chang Fan is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Medicine & Heat shock protein. The author has an hindex of 48, co-authored 121 publications receiving 7626 citations. Previous affiliations of Guo-Chang Fan include Chinese Academy of Sciences & Wuhan University.
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Journal ArticleDOI
MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20
Xiao Ping Ren,Jinghai Wu,Xiaohong Wang,Maureen A. Sartor,Jiang Qian,Keith A. Jones,Persoulla Nicolaou,Tracy J. Pritchard,Guo-Chang Fan +8 more
TL;DR: It is demonstrated that miR-320 is involved in the regulation of I/R-induced cardiac injury and dysfunction via antithetical regulation of Hsp20, a known cardioprotective protein, and may constitute a new therapeutic target for ischemic heart diseases.
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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human
Kobra Haghighi,Fotis Kolokathis,Luke Pater,Roy A. Lynch,Michio Asahi,Anthony O. Gramolini,Guo-Chang Fan,Dimitris Tsiapras,Harvey S. Hahn,Stamatis Adamopoulos,Stephen B. Liggett,Gerald W. Dorn,David H. MacLennan,Dimitrios Th. Kremastinos,Evangelia G. Kranias +14 more
TL;DR: A naturally-occurring loss-of-function human PLN mutation (PLN null) is described, in contrast to reported benefits of PLN ablation in mouse heart failure, humans lacking PLN develop lethal dilated cardiomyopathy.
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MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response.
TL;DR: Recent findings in miRNA expression profiles in polarized macrophages from murine and human sources are highlighted, and how these miRNAs regulate macrophage polarization is summarized.
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Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells.
Xiaohong Wang,Wei Huang,Guan-Sheng Liu,Wenfeng Cai,Ronald W. Millard,Yigang Wang,Jiang Chang,Tianqing Peng,Guo-Chang Fan +8 more
TL;DR: Cardiomyocytes exert an anti-angiogenic function in type 2 diabetic rats through exosomal transfer of miR-320 into endothelial cells, providing a novel mechanism underlying diabetes mellitus-induced myocardial vascular deficiency which may be caused by secretion of anti-Angiogenic exosomes from cardiomyocyes.
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A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy
Kobra Haghighi,Fotis Kolokathis,Anthony O. Gramolini,Jason R. Waggoner,Luke Pater,Roy A. Lynch,Guo-Chang Fan,Dimitris Tsiapras,Rohan R. Parekh,Gerald W. Dorn,David H. MacLennan,Dimitrios Th. Kremastinos,Evangelia G. Kranias +12 more
TL;DR: By chronic suppression of sarcoplasmic reticulum Ca2+-ATPase activity, the nonreversible superinhibitory function of mutant PLN-R14Del may lead to inherited dilated cardiomyopathy and premature death in both humans and mice.