Stephen B. Liggett

TL;DR: The results indicate that the unique interactions of multiple SNPs within a haplotype ultimately can affect biologic and therapeutic phenotype and that individual SNPs may have poor predictive power as pharmacogenetic loci.

TL;DR: Three naturally occurring polymorphisms of the human beta 2-adrenergic receptor caused by missense mutations encoding for amino acids 16 and 27 of the extracellular N-terminus of the receptor are delineated and the functional consequences of these polymorphisms by site-directed mutagenesis and the recombinant expression of these receptors in Chinese hamster fibroblasts are studied.

TL;DR: The Gαq overexpressor exhibits a biochemical and physiologic phenotype resembling both the compensated and decompensated phases of human cardiac hypertrophy and suggests a common mechanism for their pathogenesis.

TL;DR: The gene encoding the beta 2AR was examined to assess the frequency of polymorphisms in patients with moderate to severe asthma and normal subjects, and one mutation identified a subset of patients with a distinct clinical profile.

TL;DR: Genotype at the 16th aminoacid residue of the beta2-adrenergic receptor affects the long-term response to albuterol use and Bronchodilator treatments avoiding albutersol may be appropriate for patients with the Arg/Arg genotype.