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Guo-Qiang Bi
Researcher at University of Science and Technology of China
Publications - 117
Citations - 13416
Guo-Qiang Bi is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Postsynaptic potential & Excitatory postsynaptic potential. The author has an hindex of 35, co-authored 104 publications receiving 11243 citations. Previous affiliations of Guo-Qiang Bi include University of California, Berkeley & Carnegie Mellon University.
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Journal ArticleDOI
Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type
Guo-Qiang Bi,Mu-ming Poo +1 more
TL;DR: The results underscore the importance of precise spike timing, synaptic strength, and postsynaptic cell type in the activity-induced modification of central synapses and suggest that Hebb’s rule may need to incorporate a quantitative consideration of spike timing that reflects the narrow and asymmetric window for the induction of synaptic modification.
Journal ArticleDOI
Synaptic Modification by Correlated Activity: Hebb's Postulate Revisited
Guo-Qiang Bi,Mu-ming Poo +1 more
TL;DR: Spike timing-dependent modifications, together with selective spread of synaptic changes, provide a set of cellular mechanisms that are likely to be important for the development and functioning of neural networks.
Journal ArticleDOI
Stable Hebbian Learning from Spike Timing-Dependent Plasticity
TL;DR: The results indicate that stable correlation-based plasticity can be achieved without introducing competition, suggesting that plasticity and competition need not coexist in all circuits or at all developmental stages.
Journal ArticleDOI
Cell membrane resealing by a vesicular mechanism similar to neurotransmitter release
TL;DR: In this article, the authors showed that the calcium-dependent mechanisms for cell membrane resealing may involve vesicle delivery, docking, and fusion, similar to the exocytosis of neurotransmitters.
Journal ArticleDOI
Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes.
Sang Hee Shim,Chenglong Xia,Guisheng Zhong,Guisheng Zhong,Hazen P. Babcock,Joshua C. Vaughan,Joshua C. Vaughan,Bo Huang,Xun Wang,Cheng Xu,Guo-Qiang Bi,Xiaowei Zhuang +11 more
TL;DR: This work identified photoswitchable membrane probes and obtained super-resolution fluorescence images of cellular membranes, and demonstrated the photoswitching capabilities of eight commonly used membrane probes, each specific to the plasma membrane, mitochondria, the endoplasmic recticulum (ER) or lysosomes.