G
Gurunathan Jayaraman
Researcher at VIT University
Publications - 72
Citations - 1840
Gurunathan Jayaraman is an academic researcher from VIT University. The author has contributed to research in topics: Circular dichroism & Protease. The author has an hindex of 22, co-authored 71 publications receiving 1593 citations. Previous affiliations of Gurunathan Jayaraman include National Tsing Hua University & National Taiwan University.
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Journal ArticleDOI
Proline inhibits aggregation during protein refolding
Dharmaraj Samuel,Thallampuranam Krishnaswamy S. Kumar,Gopal Ganesh,Gurunathan Jayaraman,Pey-Wen Yang,Mei-Ming Chang,Vishwa Deo Trivedi,Sue-Lein Wang,Kuo Chu Hwang,Ding-Kwo Chang,Chin Yu +10 more
TL;DR: The results of this study hint at the possibility of proline behaving as a protein folding chaperone in addition to its role in osmoregulation under water stress conditions.
Journal ArticleDOI
The mechanism of 2,2,2-trichloroacetic acid-induced protein precipitation
Thirunavukkarasu Sivaraman,Thallapuranam Krishnaswamy Suresh Kumar,Gurunathan Jayaraman,Chin Yu +3 more
TL;DR: It is demonstrated that CTX III is in a partially structured state similar to the ‘A state’ in 3% w/v TCA, and it is postulated that the formation of this ‘sticky’ partial structured ’A state' in the TCA-induced unfolding pathway is responsible for the acid-induced protein precipitation.
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Production of extracellular protease from halotolerant bacterium, Bacillus aquimaris strain VITP4 isolated from Kumta coast
TL;DR: Effect of various salts indicated favourable bacterial growth in these conditions for producing proteolytic molecules with increased activity and assumes significance in the ability of the halotolerant bacterium to survive in a wide range of salinity and yield optimum levels of extracellular protease.
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Snake Venom Cardiotoxins-Structure, Dynamics, Function and Folding
Thallapuranam Krishnaswamy Suresh Kumar,Gurunathan Jayaraman,Christina S. Lee,A.I Arunkumar,Thirunavukkarasu Sivaraman,Dharmaraj Samuel,C. Yu +6 more
TL;DR: This comprehensive review is to summarize and critically evaluate the progress in research on the structure, dynamics, function and folding aspects of snake venom cardiotoxins.
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The role of proline in the prevention of aggregation during protein folding in vitro
Thallapuranam Krishnaswamy Suresh Kumar,Dharmaraj Samuel,Gurunathan Jayaraman,Thiagarajan Srimathi,C. Yu +4 more
TL;DR: Results of viscosity and ANS fluorescence experiments suggest that proline at high concentrations forms an ordered supramolecular assembly, and this is the first report wherein proline is proposed as a protein folding aid.