Gustav Mattiasson

TL;DR: It is proposed that UCP-2 is an inducible protein that is neuroprotective by activating cellular redox signaling or by inducing mild mitochondrial uncoupling that prevents the release of apoptogenic proteins.

TL;DR: UCP2 has an important role in the pathogenesis of type 2 diabetes by inhibiting insulin secretion in islet beta cells and is associated with increased risk of cardiovascular disease and atherosclerosis, which illustrates that therapeutic applications involving UCP2 likely will have to regulate expression and activity in a tissue-specific manner.

TL;DR: Two new nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 are evaluated for their ability to inhibit mPT in rat brain-derived mitochondria and will be instrumental in the evaluation of mPT as a central target for neuroprotection in vivo.

TL;DR: It is demonstrated that immortalized neural stem cells that have been retrovirally transduced to produce NGF can markedly improve cognitive and neuromotor function and rescue hippocampal CA3 neurons when transplanted into the injured brain during the acute posttraumatic period.

TL;DR: In this article, the authors developed a protocol for flow cytometric analysis of very small samples of isolated brain mitochondria, and analyzed mitochondrial swelling and formation of reactive oxygen species (ROS) in mitochondria from the CA1 and CA3 regions of the hippocampus.