T
Tracy K. McIntosh
Researcher at University of Pennsylvania
Publications - 279
Citations - 30967
Tracy K. McIntosh is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Traumatic brain injury & Hippocampus. The author has an hindex of 96, co-authored 279 publications receiving 30043 citations. Previous affiliations of Tracy K. McIntosh include Rutgers University & University of California, San Francisco.
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Journal ArticleDOI
Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model
Tracy K. McIntosh,Robert Vink,Linda Noble,I. Yamakami,Susan E Fernyak,Holly Soares,A. L. Faden +6 more
TL;DR: The lateral model of fluid-percussion injury in the rat reproduces many of the features of head injury observed in other models and species and may therefore be a useful experimental model for the study of the pathophysiology of traumatic brain injury.
Journal ArticleDOI
Clinical trials in head injury
Raj K. Narayan,Mary Ellen Michel,Beth Ansell,Alex Baethmann,Anat Biegon,Michael B. Bracken,M. Ross Bullock,Sung C. Choi,Guy L. Clifton,Charles F. Contant,William M. Coplin,W. Dalton Dietrich,Jamshid Ghajar,Sean M. Grady,Robert G. Grossman,Edward D. Hall,William Heetderks,David A. Hovda,Jack Jallo,Russell L. Katz,Nachshon Knoller,Patrick M. Kochanek,Andrew I R Maas,Jeannine Majde,Donald W. Marion,A Marmarou,Lawrence F. Marshall,Tracy K. McIntosh,Emmy Miller,Noel Mohberg,J. Paul Muizelaar,Lawrence H. Pitts,Peter Quinn,Gad Riesenfeld,Claudia S. Robertson,Kenneth I. Strauss,Graham M. Teasdale,Nancy Temkin,Ronald F. Tuma,Charles E. Wade,Michael D. Walker,Michael Weinrich,John Whyte,Jack E. Wilberger,A. Byron Young,Lorraine Yurkewicz +45 more
TL;DR: The pathomechanisms of traumatic brain damage, based upon their clinical importance, are discussed and a uniform strategic approach for evaluation of potentially interesting new compounds in clinical trials, to ameliorate outcome in patients with severe head injury, is proposed.
Journal ArticleDOI
Rehabilitation of persons with traumatic brain injury
Kristjan T. Ragnarsson,W. R. Clarke,J. R. Daling,S. L. Garber,C. F. Gustafson,A. L. Holland,B. D. Jordan,J. C. Parker,M. A. Riddle,E. J. Roth,M. M. Seltzer,K. N. Simpson,B. Therrien,B. E. Wexler,B. P. Yawn,J. Banja,D. D. Cardenas,R. M. Chesnut,D. N. Cope,John D. Corrigan,G. DeJong,W. T. Greenough,Allen W. Heinemann,M. V. Johnston,J. F. Kraus,J. S. Kreutzer,H. S. Levin,Tracy K. McIntosh,Kenneth J. Ottenbacher,J. T. Povlishock,George P. Prigatano,T. M. Rankin,Mitchell Rosenthal,R. M. Ruff,D. T. Stuss,David J. Thurman,J. Whyte,M. Ylvisaker,D. Alexander,B. Ansel,G. Cheung,M. E. Cheung,M. Coopey,J. M. Elliott,J. H. Ferguson,M. J. Fuhrer,William H. Hall,C. E. Henderson,D. Heppel,D. Krotoski,T. S. Lawrence,D. Lehmkuhl,A. Salazar,C. R. Sherman,H. D. Sigmon,S. M. Tuel,B. Vitiello,J. M. Whalen,G. A. Zitnay,J F Jr Batley,S. E. Hyman,G. D. Fischbach,P. A. Grady,W. B. Jonas,V. W. Pinn,J. M. Eisenberg,J. P. Koplan +66 more
TL;DR: This statement provides state-of-the-art information regarding effective rehabilitation measures for persons who have suffered a traumatic brain injury (TBI) and presents the conclusions and recommendations of the consensus panel regarding these issues.
Journal ArticleDOI
Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus
TL;DR: A momentary impact to the surface of the brain can cause selective, bilateral hippocampal injury with associated abnormalities in dentate gyrus physiology, and the pattern of cell loss is similar to that observed in some patients with temporal lobe epilepsy.
Journal Article
Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.
Andreas D. Rink,Kar-Ming Fung,John Q. Trojanowski,Virginia M.-Y. Lee,Edmund Neugebauer,Tracy K. McIntosh +5 more
TL;DR: Using the terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) method, data suggest that apoptosis, in addition to necrotic cell death, occurs after traumatic brain injury, and that internucleosomal fragmentation of DNA may be associated with certain types of necrotIC cell death.