P
Peter C. Waldmeier
Researcher at Novartis
Publications - 78
Citations - 3177
Peter C. Waldmeier is an academic researcher from Novartis. The author has contributed to research in topics: Dopamine & Serotonin. The author has an hindex of 29, co-authored 78 publications receiving 3105 citations.
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Journal ArticleDOI
Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811.
TL;DR: It is concluded that NIM811 is a useful alternative to PKF220-384 to investigate the role of the mitochondrial permeability transition in apoptotic and necrotic cell death.
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Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl.
Eddy A. Kragten,Isabelle Lalande,Kaspar Zimmermann,Silvio Roggo,Patrick Schindler,Dieter Müller,Jan van Oostrum,Peter C. Waldmeier,Peter Fürst +8 more
TL;DR: CGP 3466 is a structurally related analog ofR-(−)-deprenyl that exhibits virtually no monoamine oxidase type B inhibiting activity but is neuroprotective in the picomolar concentration range.
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Cyclophilin D as a drug target.
TL;DR: Structural considerations suggest feasibility of designing CYP D ligands without immunosuppressant properties, which is highly desirable, since they have the potential of being useful therapeutic agents in a variety of disease states.
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Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice
Klemens Kaupmann,John F. Cryan,Petrine Wellendorph,Cedric Mombereau,Gilles Sansig,Klaus Klebs,Markus Schmutz,Wolfgang Froestl,Herman van der Putten,Johannes Mosbacher,Hans Bräuner-Osborne,Peter C. Waldmeier,Bernhard Bettler +12 more
TL;DR: It appears that all studied GHB effects are GABAB receptor dependent, and the GHB‐induced GTPγ[35S] responses are mediated by GABAB receptors.
Journal ArticleDOI
Serotonin-dopamine interactions in the nigrostriatal system
TL;DR: Results seem to make it worthwhile to test a combination of haloperidol and a serotonin antagonist in schizophrenic patients to see whether the ratio of the therapeutic effect to the extrapyramidal side effects can be improved.