Gustavo Petroni

TL;DR: For patients with severe traumatic brain injury, care focused on maintaining monitored intracranial pressure at 20 mm Hg or less was not shown to be superior to care based on imaging and clinical examination.

TL;DR: Mortality from severe TBI is high in Latin American LMIC, although the rate of favorable recovery is similar to that of high-income countries, and Demographic factors such as race and study site played an outsized role in predicting outcome.

TL;DR: Although this protocol should produce similar/acceptable results under circumstances comparable to those in the trial, influences such as longer pre-hospital times and non-specialist transport personnel, plus an intensive care unit model of aggressive physician-intensive care by small groups of neurotrauma-focused intensivists, support caution in expecting the same results in dissimilar settings.

TL;DR: This study provides rigorous, prospective data that validates the generalizability of the five World Health Organization/Organization Mondiale de la Santé TBI prognostic predictors outside of the developed world, and provides outcome benchmarks for mortality and morbidity from severe TBI in developing countries.

TL;DR: This algorithm provides the first comprehensive management algorithm for treating sTBI patients when ICP monitoring is not available, and is intended to provide a framework to guide clinical care and direct future research toward sTBO management.