Gustavo Tapia

TL;DR: Because antiinflammatory agents are already on the market, further clinical trials should be done to evaluate this effect in humans as soon as possible, to determine their suitability as coadjuvant tuberculosis treatment.

TL;DR: DBA/2 mice are more susceptible than C57BL/6 mice to M. tuberculosis infection due to a higher bronchial dissemination of bacilli inside poorly activated foamy macrophages.

TL;DR: Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post- Infection in the murine model of tuberculosis.

TL;DR: These findings suggest that the infection induces an initial Th1 response, which is followed by local fibrosis and encapsulation of the granulomas, thereby decreasing the onset of new lesions, which could be key to a better understanding tuberculosis infection control in humans.

TL;DR: The observation of massive neutrophilic infiltration in the C3HeB/FeJ mouse model suggests that inflammation may be a key factor in progression towards active tuberculosis.