Showing papers in "Vaccine in 2005"

TL;DR: This eclectic technology, called 'magnifection', combines advantages of three biological systems: vector efficiency and efficient systemic DNA delivery of Agrobacterium, speed and expression level/yield of a plant RNA virus, as well as posttranslational capabilities and low production costs of a plants.

TL;DR: The genotypes show a distinct geographical distribution between and even within regions, and are proving to be an invaluable tool in tracing the molecular evolution and patterns and modes of spread of hepatitis B virus.

TL;DR: In this article, a review of the SBA activity as a correlate of protection for evaluating the immune response to meningococcal vaccines is described, and the proportions of vaccines with > or =4-fold rises in SBA pre-to-post-vaccination or SBA titres < or = 4 have been correlated with clinical efficacy in trials of outer membrane vesicle (OMV) vaccines in Cuba, Brazil and Norway.

TL;DR: Using a stochastic simulation model of influenza transmission, clinical illness, and economic costs, the population-wide benefits of routinely vaccinating US children against influenza are estimated.

TL;DR: Protection against challenge was T cell-dependent and substantially more potent than DNA vaccination alone, and gene-based vaccination with NP may contribute to protective immunity against diverse influenza viruses through its ability to stimulate cellular immunity.

TL;DR: This paper suggests that an annual influenza immunization should be required for every health care worker with direct patient contact, unless a medical contraindication or religious objection exists, or an informed declination is signed by the health care workers.

TL;DR: VLPs exhibited functional characteristics of influenza virus including hemagglutination and neuraminidase activities and elicited serum antibodies specific for influenza A/Hong Kong/1073/99 (H9N2) virus and inhibited replication of the influenza virus after challenge in BALB/c mice.

TL;DR: It was concluded that antigen internalization by dendritic cells was enhanced when the antigen remained adsorbed to the aluminum-containing adjuvants following administration and the aggregate size of the adjuvant was smaller than dendrite cells which are approximately 10 microm in diameter.

TL;DR: An open-labeled, non-randomized, community-based trial in children with the cold adapted influenza vaccine, trivalent (CAIV-T) was initiated to determine the coverage necessary to reduce spread of influenza in the community.

TL;DR: It is suggested that MeNZB is safe and is likely to confer protection against systemic group B meningococcal disease caused by the epidemic strain.

TL;DR: Very few patients may develop some autoimmune diseases following viral vaccination, but for the overwhelming majority of people, vaccines are safe and no evidence linking viral vaccines with type 1 diabetes, multiple sclerosis (MS) or inflammatory bowel disease can be found.

TL;DR: It is shown, in two independent experiments, that vaccination of primates with Ag85B-ESAT-6 induces protective immune responses, suggesting that Ag85 B-ESat-6 is a strong candidate for further clinical evaluation.

TL;DR: Although the future seems bright on the HPV vaccine front policy makers are strongly cautioned to avoid scaling back cervical cancer screening, it will take many years before the authors can rationally develop cervical cancer Screening strategies that will be cost-effective for the proper surveillance of women protected by HPV vaccination.

TL;DR: The results indicated that both the live and inactivated vaccines protected against morbidity and mortality and significantly reduced the incidence and viral titers shed from chickens in comparison with sham controls, but did not prevent infection and virus shedding.

TL;DR: Based on the results of this study, the best current strategy for hepatitis B vaccination in HIV patients would be to use a double dose as a primary series when the viral load is likely to be low and CD4> or = 350, when there is probably to be an adequate immune response.

TL;DR: It is reported here that adenovirus-vectored nasal and epicutaneous influenza vaccines were well tolerated by human volunteers and provide the foundation for further human testing of needleless vectored vaccines as promising alternatives to current vaccines.

TL;DR: Pvs25H generates transmission blocking immunity in humans against P. vivax demonstrating the potential of this antigen as a component of a transmission blocking vaccine.

TL;DR: This short review focuses on glycosylation and proteolytic processing of plant-made pharmaceuticals during their transport through the plant cell's secretory pathway and the practical implications of these important processes on the effectiveness of plant molecular pharming systems.

TL;DR: In this context, there is a need for more efficacious inactivated influenza vaccines, since current formulations show suboptimal immunogenicity in at-risk populations, like the elderly, and more effective vaccines are also urgently needed for an improved influenza pandemic preparedness.

TL;DR: It was evaluated its antigenicity, immunogenicity and efficacy of a candidate recombinant hepatitis E virus (HEV) vaccine, referred hitherto as HEV 239, which has a 26 amino acids extension from the N terminal of another peptide, E2, of the HEV capsid protein.

TL;DR: The consultation made a series of recommendations for specifications on immunological criteria to assess JE vaccine efficacy, and more detailed recommendations will be drafted following further consultations to serve as WHO guidelines for evaluation and licensure for new JE vaccines.

TL;DR: It is concluded that immunological responsiveness to vaccination decreases throughout adult life, and that conventional vaccination strategies designed for children and young adults cannot be uncritically applied in the elderly.

TL;DR: Among measles unvaccinated infants in Guinea-Bissau, case infants with acute lower respiratory tract infection (ALRI), especially ALRI caused by respiratory syncytial virus (RSV), were more likely to be Bacille Calmette Guerin (BCG)-un vaccinated and to have no scar after BCG vaccination than were control infants without symptoms of ALRI.

TL;DR: LZ used as live challenge to test vaccine candidates reduces the required sample size, is cost effective for surrogate markers studies and will induce protection in the participants who are not protected by candidate vaccines.

TL;DR: S. mansoni infection reduces the protective efficacy of BCG vaccination against M. tuberculosis possibly by attenuation of protective immune responses to mycobacterial antigens and/or by polarizing the general immune response to the Th2 profile.

TL;DR: Data show that nasal immunisation with chitosan plus trivalent inactivated influenza is a potentially effective, easily-administered form of vaccination.

TL;DR: The goal of the Malaria Vaccine Program at the Walter Reed Army Institute of Research is to develop a licensed multi-antigen, multi-stage vaccine able to prevent all symptomatic manifestations of malaria by preventing parasitemia.

TL;DR: The state of the art in vaccine R&D against ARIs is reviewed and an attempt is made to address basic public health questions about immunity against an avian influenza virus pandemic.

TL;DR: It was found that the reporting rates of serious adverse events were significantly higher among vaccinees aged > or =60 years than among those 19-29 years of age, and the risk for severe illness and death due to yellow fever infection should be balanced against the risk of a serious adverse event due to YEL.

TL;DR: The data suggest that enhanced hepatitis is linked to vaccination with rMVA expressing SARS-CoV antigens, and the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (MVA) expressing SARV spike or nucleocapsid proteins in ferrets are evaluated.