G
Gwen Sanderson
Researcher at Southampton General Hospital
Publications - 4
Citations - 874
Gwen Sanderson is an academic researcher from Southampton General Hospital. The author has contributed to research in topics: Asthma & Rhinovirus. The author has an hindex of 4, co-authored 4 publications receiving 823 citations.
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Journal ArticleDOI
Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production.
Simon D. Message,Vasile Laza-Stanca,Patrick Mallia,Hayley L. Parker,Jie Zhu,Tatiana Kebadze,Marco Contoli,Gwen Sanderson,Onn Min Kon,Alberto Papi,Peter K. Jeffery,Luminita A. Stanciu,Sebastian L. Johnston +12 more
TL;DR: Increased RV-induced clinical illness severity in asthmatic compared with normal subjects is demonstrated, evidence of strong relationships between virus load, lower airway virus-induced inflammation and asthma exacerbation severity is provided, and indicates augmented Th2 or impaired Th1 or IL-10 immunity are likely important mechanisms.
Journal ArticleDOI
Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study
TL;DR: Allergens and viruses may act together to exacerbate asthma, indicating that domestic exposure to allergens acts synergistically with viruses in sensitised patients, increasing the risk of hospital admission.
Journal ArticleDOI
Immunohistochemical Analysis of Nasal Biopsies during Rhinovirus Experimental Colds
David J. Fraenkel,P. G. Bardin,P. G. Bardin,Gwen Sanderson,Fiona Lampe,Sebastian L. Johnston,Stephen T. Holgate +6 more
TL;DR: It is suggested that rhinoviral colds are not associated with increased inflammatory cellularity and that other mechanisms, such as increased mediator release, are responsible for coryzal symptoms.
Journal ArticleDOI
Comparison of 3' and 5' biotin labelled oligonucleotides for in situ hybridisation.
P. G. Bardin,Mark A. Pickett,Stephen Robinson,Gwen Sanderson,Stephen T. Holgate,Sebastian L. Johnston +5 more
TL;DR: The 5′-attachment of biotin residues can extend the value of oligonucleotide probes employed for in situ hybridisation and yield increased sensitivity when combined with 3′-enzymatic labelling.