P
Peter K. Jeffery
Researcher at National Institutes of Health
Publications - 85
Citations - 13599
Peter K. Jeffery is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & Eosinophil. The author has an hindex of 51, co-authored 85 publications receiving 13297 citations. Previous affiliations of Peter K. Jeffery include Imperial College London.
Papers
More filters
Journal ArticleDOI
Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.
TL;DR: The light and electron microscopic structure of lobar bronchial biopsies taken at fiberoptic bronchoscopy from 11 atopic asthmatics, four of which were symptomatic and seven of whom were asymptomatic, was studied to study the structural changes in mild asthma.
Journal ArticleDOI
Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma.
May Azzawi,B. Bradley,Peter K. Jeffery,Anthony J. Frew,Andrew J. Wardlaw,Knowles G,B. Assoufi,J.V. Collins,Stephen R. Durham,A. B. Kay +9 more
TL;DR: Examination of mucosal biopsies obtained from both central and subsegmental bronchi showed that the highest number of CD45-, DC3-, DC4-, and CD8-positive cells were found in the group with asthma, and there was a significant increase in the number of interleukin-2 receptor (CD25)-positive cells.
Journal ArticleDOI
Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.
Qutayba Hamid,May Azzawi,Sun Ying,Redwan Moqbel,Andrew J. Wardlaw,Christopher Corrigan,B. Bradley,Stephen R. Durham,J.V. Collins,Peter K. Jeffery +9 more
TL;DR: Evidence is provided for the cellular localization of IL-5 mRNA in the bronchial mucosa of asthmatics and supports the concept that this cytokine regulates eosinophil function in Bronchial asthma.
Journal ArticleDOI
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.
Natasha J. Caplen,Eric W.F.W. Alton,Peter G. Mddleton,Julia R. Dorin,Barbara J Stevenson,Xiang Gao,Stephen R. Durham,Peter K. Jeffery,Margaret E. Hodson,Charles Coutelle,Leaf Huang,David J. Porteous,Robert Williamson,Duncan M. Geddes +13 more
TL;DR: A partial restoration of the deficit between CF and non-CF subjects of 20% was seen for the response to low Cl− perfusion following CFTR cDNA administration and it is likely that transfection efficiency and the duration of expression will need to be increased for therapeutic benefit.
Journal ArticleDOI
Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1.
TL;DR: The data confirm the involvement of subepithelial T lymphocytes and macrophages in smoking-induced airflow limitation and provide novel data which support the view that COPD is distinct from asthma with respect to the predominance of the CD8+ T-cell subset in this smoking-related condition.