Tatiana Kebadze

TL;DR: In this paper, the authors show deficient induction of interferon-λs by rhinovirus in primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus induced asthma exacerbation and virus load in experimentally infected human volunteers.

TL;DR: In this paper, the authors investigated biomarker expression in COPD exacerbations to identify biologic clusters and determine biomarkers that recognize clinical exacerbation phenotypes, namely those associated with bacteria, viruses, or eosinophilic airway inflammation.

TL;DR: Data suggest viral infections interact with atopy in infancy to promote later asthma, and protection of “high-risk” children against the effects of severe respiratory infections during infancy may represent an effective strategy for primary asthma prevention.

TL;DR: Natural virus infection and real life allergen exposure in allergic asthmatic children increase the risk of hospital admission.

TL;DR: Increased RV-induced clinical illness severity in asthmatic compared with normal subjects is demonstrated, evidence of strong relationships between virus load, lower airway virus-induced inflammation and asthma exacerbation severity is provided, and indicates augmented Th2 or impaired Th1 or IL-10 immunity are likely important mechanisms.