Showing papers by "H F Bunn published in 1993"

TL;DR: The properties of the muteins that were tested are consistent with the proposed model of tertiary structure, and this small disulfide loop is not critical to Epo's stability or function.

TL;DR: The regulation of erythropoietin (Epo) production was investigated by competitive polymerase chain reaction, a highly sensitive and accurate means of measuring Epo mRNA levels, an effective measurement of message stability.

TL;DR: Deduced amino acid sequences of mature Epo proteins from these animals, in combination with known sequences for human, Cynomolgus monkey, and mouse, showed a high degree of homology, which explains the biologic and immunological cross-reactivity that has been observed in a number of species.

TL;DR: Analysis of additional sequences shows considerable homology between human and mouse Epo genes as far as 4 kb (human) or 3 kb (mouse) upstream of the cap sites, as well as far more homology at the 3′ end than was previously realized.