H. G. Kunkel

TL;DR: Serial studies of serum specimens from patients with systemic lupus erythematosus (SLE) indicated that anti-NDNA antibodies were closely associated with disease activity, and the frequent increase of anti-SDNA antibodies in SLE and other diseases associated with active tissue destruction suggest that SDNA is a ubiquitous antigen that may stimulate the formation of antibodies reactive with a variety of polynucleotides.

TL;DR: Electron microscopic studies of the SRBC-R suggest that there are relatively few sites of attachment between the reactive lymphocyte and SRBC, which is distinguished from binding of complement-coated SRBC to the C3 receptor-bearing lymphocyte, in which broad zones of attachment are observed.

TL;DR: Evidence was obtained that 7S γG globulin rheumatoid factors represented an important constituent of the complexes and a relationship was encountered between the amount of γ globulin complex present in the joint fluids and diminution in total haemolytic complement activity.

TL;DR: Serological studies, immunofluorescence studies, and immunochemical assays of glomerular eluates indicate that several antigen-antibody systems may be involved in the pathogenesis of the tissue lesions of SLE and that rheumatoid factor contributes to the immune complex deposition in certain patients.

TL;DR: Evidence is presented that both rheumatoid factors and C1q interact with circulating complexes in patients with SLE and that the interaction is related to cryoprecipitation, suggesting that rheumatic factors have a special significance in the presence of circulating complexes.