David Koffler

TL;DR: Serial studies of serum specimens from patients with systemic lupus erythematosus (SLE) indicated that anti-NDNA antibodies were closely associated with disease activity, and the frequent increase of anti-SDNA antibodies in SLE and other diseases associated with active tissue destruction suggest that SDNA is a ubiquitous antigen that may stimulate the formation of antibodies reactive with a variety of polynucleotides.

TL;DR: Serological studies, immunofluorescence studies, and immunochemical assays of glomerular eluates indicate that several antigen-antibody systems may be involved in the pathogenesis of the tissue lesions of SLE and that rheumatoid factor contributes to the immune complex deposition in certain patients.

TL;DR: Evidence is presented that both rheumatoid factors and C1q interact with circulating complexes in patients with SLE and that the interaction is related to cryoprecipitation, suggesting that rheumatic factors have a special significance in the presence of circulating complexes.

TL;DR: Impairment of the blood-brain barrier in SLE may be secondary to the central nervous system lesion, rather than a result of systemic immune complex injury, and substantial evidence is provided for an ongoing humoral immune response within thecentral nervous system in this disorder.

TL;DR: Antibodies to native DNA occurred almost exclusively in serum of patients in the active stages of systemic lupus erythematosus, whereas antibodies to single-stranded DNA were observed in the serums of patients with several diseases and of some normal individuals.