Factors affecting the survival of mouse embryos cryopreserved by vitrification.

Arginine: biochemistry, physiology, and therapeutic implications.

Cancer a Comprehensive Treatise 2

The preceding paper described our numerical index of carcinogenic potency, the TD50 and the statistical procedures adopted for estimating it from experimental data. This paper presents the Carcinogenic Potency Database, which includes results of about 3000 long-term, chronic experiments of 770 test compounds. Part II is a discussion of the sources of our data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. Part III is a guide to the plot of results presented in Part IV. A number of appendices are provided to facilitate use of the database. The plot includes information about chronic cancer tests in mammals, such as dose and other aspects of experimental protocol, histopathology and tumor incidence, TD50 and its statistical significance, dose response, author's opinion and literature reference. The plot readily permits comparisons of carcinogenic potency and many other aspects of cancer tests; it also provides quantitative information about negative tests. The range of carcinogenic potency is over 10 million-fold.

A carcinogenic potency database of the standardized results of animal bioassays

Summary The effects of dietary phenobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The simultaneous feeding of AAF and phenobarbital reduced the hepatocarcinogenic effects of AAF. In contrast, the sequential feeding of AAF and phenobarbital resulted in a significant increase in the incidence of hepatomas. No ill effects were observed in rats fed phenobarbital alone. AAF and phenobarbital each stimulated the proliferation of hepatocytes, but, whereas the effect of AAF was maintained for the duration of exposure, the effect of phenobarbital was short lived. Phenobarbital fed simultaneously with AAF decreased the effect of AAF on liver cell proliferation.

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H.H. Frankel

Papers

Prevention by arginine glutamate of the carcinogenicity of acetamide in rats.

8-Hydroxyquinoline: Chronic toxicity and inhibitory effect on the carcinogenicity of N-2-fluorenylacetamide☆

Inhibition of the toxicity and carcinogenicity of N-2-fluorenylacetamide by acetanilide☆

Effects of isomers of acetotoluidide and aminobenzoic acid on the toxicity and carcinogenicity of N-2-fluorenylacetamide.