世界経済・社会統計 = World development indicators

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

Maternal mortality: who, when, where, and why

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1053/jhep.2000.9124

Liver from bone marrow in humans.

The comparison of the immunological state of pregnancy to an immunosuppressed host-graft model continues to lead research and clinical practice to ill-defined approaches. This Review discusses recent evidence that supports the idea that immunological responses at the receptive maternal-fetal interface are not simply suppressed but are instead highly dynamic. We discuss the crucial role of trophoblast cells in shaping not only the way in which immune cells respond to the invading blastocyst but also how they collectively react to external stimuli. We also discuss the role of the microbiota in promoting a tolerogenic maternal immune system and highlight how subclinical viral infections can disrupt this status quo, leading to pregnancy complications.

The unique immunological and microbial aspects of pregnancy

Recent observations have shown that treatment with high-dose intravenous gammaglobulin (IVIgG) given to the mother may improve fetal outcome in cases of severe Rh D alloimmunization. Unfortunately, the costs of this new method of treatment are too high for routine use. Therefore, we decided to apply this treatment to the fetus and to investigate whether the effect of IVIgG might be attributable to blockade of the fetal mononuclear phagocyte system. We have performed a randomized study in which 20 fetuses with severe Rh D-haemolytic disease (HDN) were treated with intrauterine intravascular red cell transfusions (IUT). In 10 of these 20 cases transfusions were followed by administration to the fetus of low-dose IVIgG (85.7 +/- 11.6 mg/kg by ultrasound-estimated fetal weight because of fetal vascular volume considerations). We compared the number of IUTs, postnatal exchange transfusions, haematocrit (Ht) and haemoglobulin (Hb) values before and after transfusion (s) needed by the newborns of the two groups. No significant differences in the transfusion requirements of the fetuses and in the clinical outcome could be demonstrated. However, the 95% confidence interval for the difference in the improvement of cord blood Ht was too wide for any conclusions. The 95% confidence interval for the difference in the improvement of Hb levels suggests that any clinically relevant advantage of IVIgG on Hb is unlikely.

No Beneficial Effect of Low-Dose Fetal Intravenous Gammaglobulin Administration in Combination with Intravascular Transfusions in Severe Rh D Haemolytic Disease

Reproductive age mortality survey to study under-reporting of maternal mortality in Surinam.

Lysosomal storage diseases are a rare but significant cause of non-immune hydrops fetalis (NIHF). In 17 cases of NIHF detected by ultrasound, the activity of five lysosomal enzymes was measured in leukocytes or plasma of 1 ml of fetal blood obtained by cordocentesis. By this approach seven lysosomal storage diseases known to present with hydrops fetalis can be diagnosed. In this series one case of mucopolysaccharidosis VII (M. Sly) was diagnosed at 20 weeks' gestation. The other samples allowed the establishment of reference ranges for lysosomal enzymes associated with NIHF in fetal blood. We conclude that, also in view of the poor prognosis of lysosomal storage diseases presenting with hydrops fetalis, the use of fetal blood for the early and fast biochemical diagnosis of these diseases is a valuable supplement in the diagnostic work-up and the management of NIHF.

Prenatal diagnosis of lysosomal storage diseases using fetal blood

The fifth Millennium Development Goal (MDG-5) aimed to improve maternal health, targeting a maternal mortality ratio (MMR) reduction of 75% between 1990 and 2015. The objective of this study was to identify all maternal deaths in Suriname, determine the extent of underreporting, estimate the reduction, audit the maternal deaths and assess underlying causes and substandard care factors. A reproductive age mortality survey was conducted in Suriname (South-American upper-middle income country) between 2010 and 2014 to identify all maternal deaths in the country. MMR was compared to vital statistics and a previous confidential enquiry from 1991 to 1993 with a MMR 226. A maternal mortality committee audited the maternal deaths and identified underlying causes and substandard care factors. In the study period 65 maternal deaths were identified in 50,051 live births, indicating a MMR of 130 per 100.000 live births and implicating a 42% reduction of maternal deaths in the past 25 years. Vital registration indicated a MMR of 96, which marks underreporting of 26%. Maternal deaths mostly occurred in the urban hospitals (84%) and the causes were classified as direct (63%), indirect (32%) or unspecified (5%). Major underlying causes were obstetric and non-obstetric sepsis (27%) and haemorrhage (20%). Substandard care factors (95%) were mostly health professional related (80%) due to delay in diagnosis (59%), delay or wrong treatment (78%) or inadequate monitoring (59%). Substandard care factors most likely led to death in 47% of the cases. Despite the reduction in maternal mortality, Suriname did not reach MDG-5 in 2015. Steps to reach the Sustainable Development Goal in 2030 (MMR ≤ 70 per 100.000 live births) and eliminate preventable deaths include improving data surveillance, installing a maternal death review committee, and implementing national guidelines for prevention and management of major complications of pregnancy, childbirth and puerperium.

/pdf/maternal-mortality-audit-in-suriname-between-2010-and-2014-a-3b453xgqt1.pdf

H. H. H. Kanhai

Papers

No Beneficial Effect of Low-Dose Fetal Intravenous Gammaglobulin Administration in Combination with Intravascular Transfusions in Severe Rh D Haemolytic Disease

Reproductive age mortality survey to study under-reporting of maternal mortality in Surinam.

Prenatal diagnosis of lysosomal storage diseases using fetal blood

Maternal mortality audit in Suriname between 2010 and 2014, a reproductive age mortality survey

Detection of fetal erythroblasts in maternal blood by onestep gradient enrichment and immunocytochemical recognition