W
Wilma E. Mesker
Researcher at Leiden University Medical Center
Publications - 166
Citations - 5637
Wilma E. Mesker is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 39, co-authored 144 publications receiving 4406 citations. Previous affiliations of Wilma E. Mesker include Leiden University & Loyola University Medical Center.
Papers
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Journal ArticleDOI
The carcinoma–stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage
Wilma E. Mesker,Jan M. C. Junggeburt,Karoly Szuhai,Pieter de Heer,Hans Morreau,Hans J. Tanke,Rob A. E. M. Tollenaar +6 more
TL;DR: The carcinoma-percentage in primary colon cancer is a factor to discriminate between patients with a poor and a better outcome of disease and can be a candidate marker to further stratify into more individual risk groups.
Journal ArticleDOI
Tumor–stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients
Esther M. de Kruijf,Johanna G. H. van Nes,Cornelis J.H. van de Velde,Hein Putter,Vincent T.H.B.M. Smit,Gerrit-Jan Liefers,Peter J. K. Kuppen,Rob A. E. M. Tollenaar,Wilma E. Mesker +8 more
TL;DR: Tumor–stroma ratio has proven to be an independent prognostic factor for RFP in breast cancer patients and especially in the triple-negative cancer subpopulation and could be easily implemented in routine daily pathology diagnostics.
Journal ArticleDOI
The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial
A. Huijbers,R.A.E.M. Tollenaar,Gabi W. van Pelt,E. C. M. Zeestraten,Susan J Dutton,Christopher C. McConkey,Enric Domingo,Vthbm Smit,Rachel Midgley,Bryan F. Warren,Elaine C. Johnstone,David J. Kerr,Wilma E. Mesker +12 more
TL;DR: The intra-tumor stroma percentage in colon cancer patients has been reported by as mentioned in this paper as a strong independent prognostic parameter and patients with a high stroma proportion within the primary tumor have a poor prognosis.
Journal ArticleDOI
Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts
Lukas J. A. C. Hawinkels,Madelon Paauwe,H. W. Verspaget,E Wiercinska,J. M. Van Der Zon,K van der Ploeg,P J Koelink,Jan H.N. Lindeman,Wilma E. Mesker,P. ten Dijke,Cornelis F. M. Sier +10 more
TL;DR: It is proposed that the interaction of tumor cells with resident fibroblasts results in hyperactivated TGF-β1 signaling and subsequent transdifferentiation of the fibro Blasts into α-SMA-positive CAFs, creating a cancer-promoting feedback loop.
Journal Article
the proportion of intra-tumor stroma as a strong prognosticator for stage Ii and Iii colon cancer patients, validation in the Victor trial
A. Huijbers,Gabi W. van Pelt,J. M. C. Junggeburt,C. C. Mcconkey,Rachel Midgley,Bryan F. Warren,E. C. Johnstone,David J. Kerr,R.A.E.M. Tollenaar,Wilma E. Mesker +9 more
TL;DR: This study confirms the intra-tumor stroma ratio as a prognostic factor and suggests this parameter could be a valuable and low cost addition to the TNM status and next to current high-risk parameters such as microsatellite instability status used in routine pathology reporting.