Übersicht über die celastraceen-inhaltsstoffe: Chemie, chemotaxonomie, biosynthese, pharmakologie

Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell.

More than 20% of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 µg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC) = 140 µg/ml and minimal bactericidal concentration (MBC) = 160 µg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC = 80 µg/ml and MBC = 90 µg/ml, organic extract obtained from aerial parts), and MY841 (MIC = 30 µg/ml and MBC = 50 µg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms.

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Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest

Seventeen fractions of extracts obtained from 11 Tanzanian medicinal plants, which had previously been shown to possess a high antimalarial activity in vitro were submitted to the 4-day suppressive test in Plasmodium berghei-infected mice, and were investigated for cytotoxic activity in human carcinoma cell lines in vitro. Several fractions administered orally to the mice (500mg/kg body weight/day) produced a significant reduction of parasitaemia. The most effective plant fractions investigated were those of the root and stem bark of Maytenus senegalensis (90% and 63% suppression of parasitaemia, respectively) and of the roots of Cissampelos mucronata (59% suppression). Highest cytotoxic activities were found with all fractions of Maytenus senegalensis (IC 50 < 1 μg/mL) and with the PE fraction of the roots of Salacia madagascariensis (median IC 50 =1.2 μg/mL for HT 29 and 2.3 μg/mL for KB).

Tanzanian medicinal plants used traditionally for the treatment of malaria: In vivo antimalarial and in vitro cytotoxic activities

The forage selection and grazing behavior of sheep in leafy spurge (Euphorbia esula L #3 EPHES)-infested pastures was examined in a 3-month grazing study conducted during the summer, 1981 No definite preference for or avoidance of leafy spurge was detected An initial 1- to 3- week avoidance was observed, followed by a steady increase in leafy spurge consumption A maximum intake of 40 to 50% of the diet per animal was observed Weight gain by ewes in pastures infested with leafy spurge was not significantly different from weight gain by ewes in pastures free of leafy spurge Results from these studies indicate that leafy spurge may be classified as a forage for sheep Sheep will consume a significant amount of vegetation while suffering neither harmful internal effects nor a significant loss of body weight Sheep can be considered an effective biological control agent

https://www.jstor.org/stable/pdfplus/4043945.pdf

Utilization of Leafy Spurge (Euphorbia esula) by Sheep

Biological and phytochemical evaluation of plants. IX. Antitumor activity of Maytenus senegalensis (Celastraceae) and a preliminary phytochemical investigation.

H.H.S. Fong

Papers

Biological and phytochemical evaluation of plants. IX. Antitumor activity of Maytenus senegalensis (Celastraceae) and a preliminary phytochemical investigation.

Biological and phytochemical evaluation of plants V: Isolation of two cytotoxic alkaloids from Chelidonium majus

Euphorbia esula L. (Euphorbiaceae) I. Preliminary phytochemical and biological evaluation

Structure elucidation of maytenonic acid, a new triterpene from Maytenus senegalensis (celastraceae).

Studies on Nigerian plants. 3. Biological and phytochemical screening of Lophira lanceolata, and the isolation of benzamide.