Showing papers in "Journal of Pharmaceutical Sciences in 1969"

TL;DR: Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).

TL;DR: The new method of dissolution rate data examination is capable of providing characterizing parameters of greater potential utility than conventional treatments heretofore used, and relationships between many of the constants in formerly derived dissolution rate equations and some equations derived in this report are shown.

TL;DR: Absorption rates from rat stomach in situ, and preliminary data showing a relationship between fasting time and intestinal absorption rates in the rat are presented are also presented.

TL;DR: The resultant glass solution is believed to represent a new class of physical modification of drugs exhibiting strikingly fast dissolution rate of griseofulvin.

TL;DR: The apparent solubility and rate of solution of sulfathiazole from compressed tablets containing polyvinylpyrrolidone (PVP) were found to be greatly increased if sulfathrazole was previously coprecipitated with PVP.

TL;DR: The definition of the constant (Vd)β is shown to be identical to the apparent volume of distribution obtained from the area under the plasma curve equation for a two-compartmental open system, and can be obtained readily without having to resort to intra venous injection and very intensive blood sampling.

TL;DR: Using in vitro techniques the penetration of 14C labeled fluminolone acetonide and its acetate ester through human skin at 37° has been examined with vehicle mixtures of isopropanol and isoproyl myristate or propylene glycol and little penetration was found.

TL;DR: Injection of methanol solutions of trimethylanilinium salts of barbiturates, phenolic alkaloids, and dimethylxanthines produced thermal decomposition in the injection port to give methyl derivatives suitable for quantitative gas chromatography.

TL;DR: The thermodynamic relationships involving the transition of the metastable polymorphs to the stable one were examined and the relative stability of the polymorphs in the dissolving media is shown.

TL;DR: The apparent partition coefficients between n-octyl alcohol and aqueous buffers (ranging from pH 2.1 to 8.5) were determined for several tetracyclines, and the zwitterionic form, −0+, appeared to be the most lipid soluble form.

TL;DR: The data obtained with acetylsalicylic acid indicate metabolism occurs in both the gut wall and in the liver, thereby causing a large reduction in the areas obtained after oral dosing or hepatic portal vein infusion when compared to the area obtained after infusion by the vena cava.

TL;DR: The binding of conjugated and unconjugated bile salts to cholestyramine from aqueous media was investigated and the data plotted according to the Langmuir adsorption equation; higher affinity constants were obtained with the dihydroxy rather than the trihydroxy derivatives.

TL;DR: Additional HLB measurements are needed to determine whether the equations used to calculate HLB fully describe the emulsifying characteristics of all nonionic surfactants, i.e., whether all experimental HLB values are really independent of the structure of the surfactant molecules.

TL;DR: The agreement between the calculated theoretical curve and the experimental points (buffer-free) supports the hypothesis presented concerning the reactions involved in the degradation of ampicillin in solution.

TL;DR: In this article, a cascade impactor was employed to measure aerosol particle size in a study designed to investigate the influence of several formulation parameters on the size of aerosol particles, such as reducing the drug particle size, reducing drug concentration, including a surfactant in the formulation, reducing the sprayorifice diameter, and increasing the propellant vapor pressure.

TL;DR: An aqueous extract of the dry flower heads of Achillea millefolium (yarrow) has been found to possess anti-inflammatory activity as measured by the mouse paw edema test, and fractionation has resulted in the isolation of a material which reduces inflammation by 35%.

TL;DR: The method, which is based on the mass transfer between solid and liquid phase in an exchange column, is shown to avoid some disadvantages of the commonly used beaker methods employing fixed liquid volumes and seems to be useful for a meaningful study of dissolution kinetics.

TL;DR: The acid degradation of the aldopentoses to furfural and the degradation offurfural were followed spectrophotometrically and are first-order functions of HCI and pentose concentration and are consistent with a positive entropic effect which implies that the transition state involves ring opening.

TL;DR: A study has been made of the antimicrobial activity of dimethyl sulfoxide (DMSO) against three organisms, Escherichia coli, Pseudomonas aeruginosa, and Bacillus megaterium.

TL;DR: Suitable pharmacologic effect data, obtained at frequent intervals after drug administration, can show whether the site of action can be considered as part of a homogeneous tissue compartment (of the two-compartment system) or if the site is considered as a distinct and separate pharmacokinetic compartment.

TL;DR: Benzoic acid has a pronounced inhibitory effect on the formation of salicyluric acid from salicylic acid, and the results indicate that in man the availability of glycine is rate-limiting in theformation of hippuric Acid, but not inThe formation of SalicylURic acid.

TL;DR: The amphoteric penicillins, ampicillin and Wy-4508 (cyclacillin), possess properties similar to the alicyclacillinphatic amino acids, and in this form are most stable and least soluble in water.

TL;DR: The pharmacokinetics of drug distribution are evaluated for two types of drug administration, viz., constant-rate intravenous infusion and instantaneous intravenous injection, and it is found that at equivalent plasma concentrations more drug will be in the tissue compartment during pseudo-distribution equilibrium than during infusion equilibrium.

TL;DR: The apparent partition coefficients between n-octyl alcohol and aqueous buffers and the general structural formula for the tetra- cycline analogs are shown, and the structures of the analogs discussed in this paper are explained in terms of the general structure.

TL;DR: Evidence is presented which clearly indicates that TCA, an anion capable of forming a lipid-soluble ion pair with isopropamide, significantly enhances the pharmacologic response of orally administered isoproamide.

TL;DR: The synthetic C-terminal octapeptide of cholecystokinin (CCK), SQ 19,844, caused CCK-like contractile activities of excised gallbladder and ileal strips of guinea pigs, ofGallbladder preparations in situ in anesthetized guinea pig, and of gallbladders and duodenal preparations in siamese dogs with gastric pouches.

TL;DR: Compressible starch gives results comparable to USP starch in terms of disintegration time and dissolution rate when used at equivalent levels and the high moisture content of compressible starch does not affect the stability of aspirin when compressed together.

TL;DR: Differential thermal analysis (DTA), the cooling curve method, and the thaw-melt method are used to obtain data from which phase diagrams are constructed for a number of binary systems, demonstrating several advantages over the more classical methods of thermal analysis.