Showing papers in "Journal of Pharmaceutical Sciences in 1971"

TL;DR: A pharmacokinetic model is presented to predict the detailed distribution and excretion of methotrexate in several mammalian species over a wide range of doses.

TL;DR: Plasma level data for propranolol in man have been used to indicate the utility of these equations, and the significance of these calculations to the design of clinical studies with new drugs intended for oral use is discussed.

TL;DR: Pertinent data are presented for the performance of 83 different microbiological assays for antibiotics, including the official methods for all antibiotics approved for human use in the United States plus methods for 10 other antibiotics.

TL;DR: Results indicate a good degree of coordination of dose administration with inhalation into the inspired air stream, and the ability of the device to dispense size‐graded fractions of lactose, in the range of 4–400 μ, was investigated.

TL;DR: A detailed crystallographic study was made to provide a better understanding and control of processing steps, purity control, and dosage formulations of cromolyn sodium.

TL;DR: Pharmacodynamic relationships were developed to characterize the necrobiotic effects of phase-nonspecific chemotherapeutic agents which attach irreversibly to cell receptors to demonstrate the usefulness and certain therapeutic implications of the equations.

TL;DR: Calculation of the mechanism of densification by two different methods showed that particle rearrangement was greatest for the smallest size fraction both at slow and high speeds.

TL;DR: Nine strains of Cannabis sativa L. sativa (marijuana) were grown for research by the University of Mississippi and the cannabinoid content was determined using GLC, and the material was divided into two chemical phenotypes according to cannabinoid content.

TL;DR: The correlations indicated that the in vivoresults were directly dependent upon penetrability, and the similarity between the in vivo and in vitrocomposition profiles for both steroids suggested that clinical efficacy can be predicted from in vitro data and from the physical properties of the steroids.

TL;DR: Oral administration of 3 g of ascorbic acid 1.5 hr after an oral dose of 1 g of acetaminophen caused a rapid and pronounced decrease in the excretion rate ofacetaminophen sulfate in five healthy adult volunteers.

TL;DR: High potency adsorbates of methapyrilene, dextromethorphan, ephedrine, and pseudoephedrine were prepared by column procedures using a polymethacrylic acid ion-exchange resin and taste evaluation showed a significant reduction in bitterness of the drugs.

TL;DR: When the rate at which the aqueous binder solution added to the fluidized bed of powders was increased, the ability of the solution to wet and penetrate the solids was enhanced, resulting in a larger average granule size and a less friable granulation.

TL;DR: Griseofulvin dispersed in polyethylene glycol 6000, prepared by the melting or solvent method, was found to be completely and rapidly absorbed after oral administration to two human subjects.

TL;DR: A competitive inhibition in the formation of acetaminophen sulfate and salicylamide sulfate is indicated and also a competitive inhibitory effect of L-cysteine is thought to have been prevented.

TL;DR: Small doses (2.5, 5, 7.0, and 10.0 mg./kg.) of 2-pyridinium aldoxime methochloride were given intramuscularly and intravenously to groups of volunteers and the oxime was rapidly eliminated in the urine.

TL;DR: A spectrophotofluorometric assay was developed and was applied to the determination of blood levels and urinary excretion in a dog following intravenous and oral administration and in two human subjects following the oral administration of flurazepam · 2HCI.

TL;DR: The addition of plasticizers generally lowered the water vapor transmission rate, moisture absorption, and water permeation but had little effect on tablet‐disintegration time, and addition of most plasticizers resulted in poorer enteric coating performance.

TL;DR: Calculations based on the increase in lag time for steady‐state penetration with vehicle composition indicated that the variation in barrier permeability was associated with a vehicle effect rather than binding.

TL;DR: By combining fluorometric and microbiological methods, measurement can be made of ampicillin degradation products as well as the unchanged antibiotic in serum and urine, allowing detection of less than 0.05 mcg./ml.

TL;DR: It is suggested that if the pharmacokinetic parameters are derived for the purpose of predicting the blood levels for different regimens or formulations of the drug—such as multiple-dose regimen or sustained-release capsules—this end can be met more expeditiously by using purely empirical techniques.

TL;DR: The biologic half-life of a drug as determined from the terminal exponential phase of appropriate semilogarithmic plots is shown to dictate the steady-state levels of drug upon repetitive dosing, regardless of how low the plasma concentrations are or how little drug remains in the body, after a single dose, before the terminalonential phase occurs.

TL;DR: The contact angles of several liquids on human skin were measured before and after extraction of surface lipids with acetone to determine the critical surface tension of the skin by extrapolating the cosines of the contact angle of the liquids as a function of their surface tensions to unity.

TL;DR: The application of numerical methods to several systems suggested that binding of drugs to plasma protein should cause detectable nonlinearity in the log C versus t plot only if doses are sufficiently high to approach saturation of binding sites or if the number ofbinding sites in plasma is small.

TL;DR: This evaluative study probably represents the first example of the rigorous application of the physical model approach to the quantitative and mechanistic interpretation of the in vivo absorption of drugs.

TL;DR: A sensitive spectrofluorometric assay of sotalol·HCl ( d,l -4-(2-isopropylamino-1-hydroxyethyl)methanesulfonanilide hydrochloride; MJ 1999), a potent and specific β-adrenergic blocking agent, was developed and is applicable for monitoring blood levels and urinary excretion of the drug when administered in therapeutic amounts.

TL;DR: N-4-Oxides of benzodiazepines were thermally labile under the gas chromatography conditions, and VII was converted partially to I by desoxygenation, while the corresponding diazepam did not give the expected thermal conversion to the nitrone, but rearranged to the 4-benzoylquinoxalinone (XII) as a major product.

TL;DR: The structural relationships between a large group of steroids and their ether—water partition coefficients were explored and Hansch-like πe values were estimated for a number of functional groups, allowing the calculation of partition coefficients of highly substituted steroids from stripped steroid skeletons.