H
H. Houlden
Researcher at University of South Florida
Publications - 13
Citations - 564
H. Houlden is an academic researcher from University of South Florida. The author has contributed to research in topics: Apolipoprotein E & Allele. The author has an hindex of 11, co-authored 13 publications receiving 535 citations. Previous affiliations of H. Houlden include Imperial College London.
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Journal ArticleDOI
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease
Mike Hutton,F. Busfield,Michelle Wragg,Richard Crook,Jordi Pérez-Tur,Robert Clark,G. Prihar,C. Conover Talbot,Phillips H,Kristal Wright,Matt Baker,C. Lendon,Karen Duff,Alonso Martínez,H. Houlden,Nichols A,Eric Karran,G.W. Roberts,P Roques,Martin N. Rossor,Venter Jc,Adams,Cline Rt,Phillips Ca,Alison Goate +24 more
TL;DR: The intron/exon structure of the gene is elucidated and intronic primers are designed to enable direct sequencing of the entire coding region (10 exons) of the presenilin gene in a large number of families.
Journal ArticleDOI
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease
Christine Van Broeckhoven,H Backhovens,Marc Cruts,Jean Jacques Martin,Richard Crook,H. Houlden,H. Houlden,John Hardy +7 more
TL;DR: This work assessed whether the APOE genotype had an influence on the age of onset of AD in chromosome 14 linked early-onset AD families and no significant effect of the APoe genotype on onset age could be detected.
Journal ArticleDOI
Polymorphism in AACT gene may lower age of onset of Alzheimer's disease
Christopher Talbot,H. Houlden,Nicholas John Craddock,Richard Crook,Mike Hutton,C. Lendon,G. Prihar,John C. Morris,John Hardy,Alison Goate +9 more
TL;DR: If AACT genotype has an effect on risk for AD it may be predominantly amongst individuals with early onset AD, while the mean age of onset was apparently lowered by the presence of the AACT AA genotype among ApoE-4 bearers.
Journal ArticleDOI
Analysis of tau haplotypes in Pick's disease
Huw R. Morris,Matthew C. Baker,K. Yasojima,H. Houlden,M. N. Khan,Nicholas W. Wood,John Hardy,Murray Grossman,John Q. Trojanowski,T Revesz,Eileen H. Bigio,Catherine Bergeron,JC Janssen,Patrick L. McGeer,Martin N. Rossor,Andrew J. Lees,Peter L. Lantos,Mike Hutton +17 more
TL;DR: There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects, and no tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.
Journal ArticleDOI
Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus.
TL;DR: It is confirmed that familial clustering in late onset Alzheimer's disease is associated with the zeta 4 allele of apolipoprotein E, and it is suggested that the effect of a single zeta4 allele is to increase the risk of developing AD by an amount equivalent to 5 years.