H
H. J. Altermatt
Researcher at University of Bern
Publications - 28
Citations - 1498
H. J. Altermatt is an academic researcher from University of Bern. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 18, co-authored 28 publications receiving 1468 citations.
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Journal ArticleDOI
The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression.
S Vonlanthen,Jim Heighway,H. J. Altermatt,Matthias Gugger,Andreas Kappeler,Markus Borner,M van Lohuizen,Daniel C. Betticher +7 more
TL;DR: The inverse correlation of bmi-1 and the INK4 locus proteins expression (p16/p14ARF) supports a possible role for bmi -1 misregulation in lung carcinogenesis.
Journal ArticleDOI
Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results.
Hans-Beat Ris,H. J. Altermatt,R. Inderbitzi,R. Hess,B. Nachbur,J. C. M. Stewart,Q. Wang,Chang Kee Lim,Raymond Bonnett,M. C. Berenbaum +9 more
TL;DR: Four patients underwent intraoperative photodynamic therapy after surgery with meso-tetra-(hydroxyphenyl)-chlorin (mTHPC-PDT) for diffuse malignant mesothelioma and one patient succumbed from aspiration pneumonia.
Journal ArticleDOI
Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer.
Daniel C. Betticher,J. Heighway,Philip S. Hasleton,H. J. Altermatt,W. D. J. Ryder,Thomas Cerny,Nick Thatcher +6 more
TL;DR: It is concluded that genetic alteration of cyclin D1 is a key abnormality in lung carcinogenesis and may have diagnostic and prognostic importance in the treatment of resectable NSCLC.
Journal ArticleDOI
Effect of drug‐light interval on photodynamic therapy with meta‐tetrahydroxyphenylchlorin in malignant mesothelioma
Hans-Beat Ris,H. J. Altermatt,B. Nachbur,J. C. M. Stewart,Qiang Wang,Chang Kee Lim,R. Bonnett,Ulrich Althaus +7 more
TL;DR: The therapeutic ratio of mTHPC‐PDT varied significantly with the time interval between drug administration and laser activation and was greatest at an interval of 3 days, and the tissue concentration of m THPC was of limited use as regards the prediction of photosen‐sitizing effects in the tumour model.
Journal ArticleDOI
Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer
Markus Borner,Pierre Brousset,B Pfanner-Meyer,M Bacchi,S Vonlanthen,Michel A. Hotz,H. J. Altermatt,D Schlaifer,John C. Reed,Daniel C. Betticher +9 more
TL;DR: The results establish the frequent expression of the BCl-2 family proteins Bcl-2, Mcl-1, Bax and Bak in NSCLC and it can be expected that B cl-2family members have no straightforward impact on clinical outcome in this disease.