H. J. Lang

TL;DR: The above described structure activity relationship renders it likely that these chloride channel blockers possess several sites of interaction: The negatively charged carboxylate group, the secondary amine group which probably carries a positive partial charge, and for the very potent agents an additional negative partial charge at the respective-Cl or-NO2 substituent.

TL;DR: This substance blocks reversibly the Cl−-conductance present under normal circumstances in the basolateral membrane of the thick ascending limb of the loop of Henle and in the apical membrane of shark rectal gland tubules, leading to a reduction in active NaCl reabsorption and secretion.

TL;DR: In summary, 293B appears to be a rather specific inhibitor of IKs and the underlying IsK channels.

TL;DR: It is concluded that 293 B inhibits the K- conductance induced by cAMP, which is apparently relevant for Cl− secretion and the basal K+ conductance is insufficient to support secretion.

TL;DR: Analysis of patch-clamp data indicates that the interaction site for arylaminobenzoates is accessible from the outer aspects of the Cl− channel facing the extracellular medium, and shows that the macromolecular probes of arieslaminoates have affinities to theCl− channel very similar to those of the respective parent compounds.