H
H Kalimo
Researcher at Karolinska Institutet
Publications - 15
Citations - 957
H Kalimo is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: CADASIL & Vascular dementia. The author has an hindex of 11, co-authored 15 publications receiving 921 citations. Previous affiliations of H Kalimo include University of Turku & Åbo Akademi University.
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Journal ArticleDOI
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
Richard Crook,Auli Verkkoniemi,Jordi Pérez-Tur,Nitin D. Mehta,Matt Baker,Henry Houlden,Matthew J. Farrer,Mike Hutton,Sarah Lincoln,John Hardy,Katrina Gwinn,Mirja Somer,Anders Paetau,H Kalimo,H Kalimo,Raija Ylikoski,Minna Pöyhönen,Steve Kucera,Matti Haltia +18 more
TL;DR: A novel variant of Alzheimer's disease in a Finnish pedigree with 17 affected individuals of both sexes in three generations caused by a deletion of exon 9 (Δ9) of the presenilin 1 (PSI) gene from the mRNA was described.
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Distribution and modulation of histamine H(3) receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease.
TL;DR: Modulation of the histamine H(3) receptor in PD is indicated at the level of the mRNA expression in the striatum and receptor density in the substantia nigra, and the receptor activity seems to be unchanged or decreased, as revealed by GTP-gamma-[(35)S]-binding assay.
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Specific and Innervation-Regulated Expression of the Intermediate Filament Protein Nestin at Neuromuscular and Myotendinous Junctions in Skeletal Muscle
Samuli Vaittinen,Riitta Lukka,Cecilia Sahlgren,Jussi Rantanen,Timo Hurme,Urban Lendahl,John E. Eriksson,H Kalimo,H Kalimo +8 more
TL;DR: This study demonstrates that the expression levels and distribution pattern of nestin are regulated by innervation, ie, signal transduction into myofibers, in intact and denervated muscle in rat and in human.
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Variant Alzheimer's disease with spastic paraparesis: clinical characterization.
Auli Verkkoniemi,Mirja Somer,Juha O. Rinne,L. Myllykangas,Richard Crook,John Hardy,Matti Viitanen,H Kalimo,Matti Haltia +8 more
TL;DR: Spastic paraparesis or brisk stretch reflexes of lower extremities or clumsiness of hands combined with dementia suggests this variant of AD.
Journal ArticleDOI
CADASIL: hereditary disease of arteries causing brain infarcts and dementia.
H Kalimo,Matti Viitanen,Kaarina Amberla,Vesa Juvonen,Reijo J. Marttila,Minna Pöyhönen,Juha O. Rinne,Marja-Liisa Savontaus,Seppo Tuisku,Bengt Winblad +9 more
TL;DR: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) begins with migraine with aura in approximately one‐third of the patients and is caused by missense point mutations in the Notch3 gene, which encodes a transmembrane receptor protein.