Biodegradable polymeric nanoparticles based drug delivery systems

Nanoparticle-based targeted drug delivery

For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes.

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Nanoparticles - A Review

Throughout the world today, numerous researchers are exploring the potential use of polymeric nanoparticles as carriers for a wide range of drugs for therapeutic applications. Because of their versatility and wide range of properties, biodegradable polymeric nanoparticles are being used as novel drug delivery systems. In particular, this class of carrier holds tremendous promise in the areas of cancer therapy and controlled delivery of vaccines.

Biodegradable nanoparticles for drug delivery and targeting

Colloidal gold, a sol comprised of nanoparticles of Au0, has been used as a therapeutic for the treatment of cancer as well as an indicator for immunodiagnostics. However, the use of these gold nan...

https://www.tandfonline.com/doi/pdf/10.1080/10717540490433895

Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery

Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation.

H.M. Redhead

Papers

Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation.