H
H Saito
Researcher at Nagoya University
Publications - 6
Citations - 758
H Saito is an academic researcher from Nagoya University. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 5, co-authored 6 publications receiving 729 citations.
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Journal ArticleDOI
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines.
Fumihiko Hayakawa,Masayuki Towatari,Hitoshi Kiyoi,Mitsune Tanimoto,Toshio Kitamura,H Saito,Tomoki Naoe +6 more
TL;DR: In this paper, the internal tandem duplication of the human Flt3 gene in approximately 20% of acute myeloid leukemia (AML) cases was identified, and the wild-type and the mutant FLt3 genes were transfected into two IL-3-dependent cell lines, 32D and BA/F3 cells.
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Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy.
Hiroshi Kosugi,Masayuki Towatari,Sonoko Hatano,Kunio Kitamura,Hitoshi Kiyoi,T Kinoshita,Mitsune Tanimoto,Takashi Murate,K Kawashima,H Saito,Tomoki Naoe +10 more
TL;DR: HDRIs are the potent inducer or enhancer of differentiation in acute myeloid leukemia and regulate transcription in an ordered manner.
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Accurate quantitation of residual tumor burden at bone marrow harvest predicts timing of subsequent relapse in patients with common ALL treated by autologous bone marrow transplantation
S Mizuta,Yoshinori Ito,Akio Kohno,Hitoshi Kiyoi,Koichi Miyamura,Mitsune Tanimoto,Junki Takamatsu,Tomoki Naoe,Yasuo Morishima,Ryuzo Ueda,H Saito +10 more
TL;DR: An accurate quantitative assessment of residual disease in the autograft has a high predictive value for subsequent relapse and would help to individualize the treatment for each patient after induction or consolidation therapy.
Journal Article
Protein expression and constitutive phosphorylation of hematopoietic transcription factors PU.1 and C/EBP beta in acute myeloid leukemia blasts.
Hiroatsu Iida,Masayuki Towatari,Minako Iida,Mitsune Tanimoto,Yoshihisa Kodera,A M Ford,H Saito +6 more
TL;DR: The first insights into both protein expression and phosphorylation of transcription factors in a large-scale study of patients with acute myeloid leukemia (AML) are presented.
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Gelatin beads as platforms for targeting molecule and anti-Fas antibody: two major properties of cytotoxic T lymphocytes
Toshiya Yokozawa,Koichi Miyamura,Ryuichi Fujino,Shin Yonehara,Ryuzo Ueda,Mitsune Tanimoto,H Saito +6 more
TL;DR: The findings suggest that antibody-carrying gelatin beads may be the first step toward the development of artificial CTL and can be applied, for example, to artificial dendritic and stroma cells for theDevelopment of novel biotherapeutic approaches.