H
Habibe Karacay
Researcher at University of Alabama
Publications - 49
Citations - 2767
Habibe Karacay is an academic researcher from University of Alabama. The author has contributed to research in topics: Pretargeting & Radioimmunotherapy. The author has an hindex of 31, co-authored 49 publications receiving 2661 citations.
Papers
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Journal ArticleDOI
A Novel Method of 18F Radiolabeling for PET
William J. McBride,Robert M. Sharkey,Habibe Karacay,Christopher A. D’Souza,Edmund A. Rossi,Peter Laverman,Chien-Hsing Chang,Otto C. Boerman,David M. Goldenberg +8 more
TL;DR: The ability to bind highly stable Al18F to metal-binding ligands is a promising new labeling method that should be applicable to a diverse array of molecules for PET.
Journal ArticleDOI
Improved 18F Labeling of Peptides with a Fluoride-Aluminum-Chelate Complex
William J. McBride,Christopher A. D’Souza,Robert M. Sharkey,Habibe Karacay,Edmund A. Rossi,Chien-Hsing Chang,David M. Goldenberg +6 more
TL;DR: Several new NOTA ligands were examined and stable Al(18)F NOTA complexes were stable in vitro in human serum, and those that were tested in vivo also were stable.
Journal Article
Molecular advances in pretargeting radioimunotherapy with bispecific antibodies.
Chien-Hsing Chang,Robert M. Sharkey,Edmund A. Rossi,Habibe Karacay,William H. McBride,Hans J. Hansen,Jean-François Chatal,Jacques Barbet,David M. Goldenberg +8 more
TL;DR: This minireview discusses the various strategies and advancements made since the concept of pretargeting was proposed in the mid-1980s, with emphasis on those comprising bispecific antibodies for cancer therapy, and critical aspects of thesepretargeting systems for achieving higher tumor:nontumor ratios are considered.
Journal ArticleDOI
Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody.
Robert M. Sharkey,Thomas M. Cardillo,Edmund A. Rossi,Chien-Hsing Chang,Habibe Karacay,William J. McBride,Hans J. Hansen,Ivan Horak,David M. Goldenberg +8 more
TL;DR: Molecular imaging of cancer is described using signal amplification of a radiotracer in situ by pretargeting a multivalent, bispecific antibody to carcinoembryonic antigen (CEA), which subsequently also captures a radioactive hapten-peptide.
Journal ArticleDOI
Improving the Delivery of Radionuclides for Imaging and Therapy of Cancer Using Pretargeting Methods
Robert M. Sharkey,Habibe Karacay,Thomas M. Cardillo,Chien-Hsing Chang,William J. McBride,Edmund A. Rossi,Ivan Horak,David M. Goldenberg +7 more
TL;DR: Pretargeting methods improve tumor/nontumor ratios, exceeding that achieved with directly radiolabeled Fab′ fragments, particularly within just a few hours of the radionuclide injection, giving pretargeting a greatly enhanced sensitivity for imaging.