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William H. McBride
Researcher at University of California, Los Angeles
Publications - 316
Citations - 20001
William H. McBride is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 72, co-authored 312 publications receiving 18404 citations. Previous affiliations of William H. McBride include UCLA Medical Center & Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
The Response of CD24 −/low /CD44 + Breast Cancer–Initiating Cells to Radiation
TL;DR: Breast cancer-initiating cells are a relatively radioresistant subpopulation of breast cancer cells and increase in numbers after short courses of fractionated irradiation, offering a possible mechanism for the accelerated repopulation of tumor cells observed during gaps in radiotherapy.
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Effects of radiation on normal tissue: consequences and mechanisms.
TL;DR: Treatments that reduce the risk or severity of damage to normal tissue or that facilitate the healing of radiation injury are being developed, which could greatly improve the quality of life of patients treated for cancer.
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CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
Jingying Xu,Jemima Escamilla,Stephen Mok,John R. David,Saul J. Priceman,Brian L. West,Gideon Bollag,William H. McBride,Lily Wu +8 more
TL;DR: The results highlight the importance of CSF 1/CSF1R signaling in the recruitment of TIMs that can limit the efficacy of radiotherapy and suggest that CSF1 inhibitors should be evaluated in clinical trials in combination with radiotherapy as a strategy to improve outcomes.
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Maximizing tumor immunity with fractionated radiation.
TL;DR: Radiation can be an immune adjuvant, but the response varies with the size of dose per fraction, and the ultimate challenge is to optimally integrate cancer immunotherapy into radiation therapy.
Journal Article
IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.
TL;DR: The results suggest IL-4 modulates monocyte production of TNF and IL-1 by down-regulation of gene expression, which may be important in the regulation of the immune response.