Improved 18F Labeling of Peptides with a Fluoride-Aluminum-Chelate Complex
William J. McBride,Christopher A. D’Souza,Robert M. Sharkey,Habibe Karacay,Edmund A. Rossi,Chien-Hsing Chang,David M. Goldenberg +6 more
TLDR
Several new NOTA ligands were examined and stable Al(18)F NOTA complexes were stable in vitro in human serum, and those that were tested in vivo also were stable.About:
This article is published in Bioconjugate Chemistry.The article was published on 2010-06-14 and is currently open access. It has received 182 citations till now.read more
Citations
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Journal ArticleDOI
Fluorine-18 radiochemistry, labeling strategies and synthetic routes.
TL;DR: The current radiosynthesis routes and strategies for 18F labeling of small molecules and biomolecules are described and the need for simple and efficient 18F-labeling procedures is described.
Journal ArticleDOI
Prospective of ⁶⁸Ga-radiopharmaceutical development.
TL;DR: The future development of the 68Ga-radiopharmaceuticals must be put in the context of several aspects such as role of PET in nuclear medicine, unmet medical needs, identification of new biomarkers, targets and corresponding ligands, production and availability of 68Ga, automation of the radiopharm pharmaceutical production, progress of positron emission tomography technologies and image analysis methodologies.
Journal ArticleDOI
Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3
TL;DR: RGD-based PET tracers used in clinical trials are summarized in terms of radiosynthesis, dosimetry, pharmacokinetics and clinical applications and a perspective of their future use in the clinic is provided.
Journal ArticleDOI
Radiopharmaceutical chemistry for positron emission tomography.
Zibo Li,Peter S. Conti +1 more
TL;DR: An overview of the most common chemical approaches for the synthesis of PET-labeled molecules is provided and the most recent developments and trends are highlighted.
Journal ArticleDOI
Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice.
Lixin Lang,Weihua Li,Ning Guo,Ying Ma,Lei Zhu,Dale O. Kiesewetter,Baozhong Shen,Gang Niu,Xiaoyuan Chen +8 more
TL;DR: Considering their ease of preparation and good imaging qualities, [(18)F]FAl-NOTA-PRGD2 and [(68)Ga]-labeled NOTA-RGD derivatives are promising alternatives to [(18]F]FPPR GD2 for PET imaging of tumor α(v)β(3) integrin expression.
References
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Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
TL;DR: This Review highlights key aspects of the synthesis of PET radiotracers with the short-lived positron-emitting radionuclides (11)C, (18)F, (15)O, and (13)N, with emphasis on the most recent strategies.
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Chemistry with [18F]Fluoride Ion
TL;DR: A review of the use of No-Carrier-added (NCA) [18F]fluoride ion in the preparation of 18F-labeled radiotracers for PET can be found in this paper.
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A Novel Method of 18F Radiolabeling for PET
William J. McBride,Robert M. Sharkey,Habibe Karacay,Christopher A. D’Souza,Edmund A. Rossi,Peter Laverman,Chien-Hsing Chang,Otto C. Boerman,David M. Goldenberg +8 more
TL;DR: The ability to bind highly stable Al18F to metal-binding ligands is a promising new labeling method that should be applicable to a diverse array of molecules for PET.
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Receptor targeting for tumor localisation and therapy with radiopeptides.
TL;DR: From biodistribution studies in experimental animals and from clinical data it is concluded that DOTATOC is currently the most suitable SRIF radiopeptide with the best potential in the clinic.
Journal ArticleDOI
Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting
Edmund A. Rossi,David M. Goldenberg,Thomas M. Cardillo,William J. McBride,Robert M. Sharkey,Chien-Hsing Chang +5 more
TL;DR: The dock and lock method is validated herein by producing bispecific, trivalent-binding complexes composed of three stably linked Fab fragments capable of selective delivery of radiotracers to human cancer xenografts, resulting in rapid, significantly improved cancer targeting and imaging.