Hachiro Senoh

TL;DR: TNFs are critical cytokines for inducing T cell activation-associated (Con A-induced) hepatitis and the induction of hepatitis is almost completely controlled by rIL-6, which exerts its protective effect through multiple mechanisms including the reduction of TNF production.

TL;DR: Results indicate that IFN‐γ plays a critical role in the development of Con A‐induced acute hepatitis and suggest that IL‐6 administration can regulate the manifestation of hepatitis through mechanisms including the reduced production of inflammatory cytokines such as IFN-γ.

TL;DR: An interleukin-6 (IL-6)-dependent cell line from murine plasmacytoma MOPC-104E cells was found to respond to murine and to human IL-6, but not to any other cytokines, and it is found that the L3T4+ T cell subset is responsible for the enhanced production of IL- 6 in arthritic mice.

TL;DR: A series of novel 1,5-diarylpyrazole derivatives was synthesized and tested for anti-inflammatory and analgesic activities to develop anti- inflammatory agents with fewer side effects than existing nonsteroidal anti- inflammation drugs.

TL;DR: Results indicate that, while IFN‐γ produced in vivo by activated T cells induces hepatic injury, there exists a striking strain difference in the induction of IFN-γ–dependent hepatic Injury.