H
Haesook Jung-Ha
Researcher at National Institutes of Health
Publications - 2
Citations - 860
Haesook Jung-Ha is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protamine & Sperm. The author has an hindex of 2, co-authored 2 publications receiving 783 citations.
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Journal ArticleDOI
Haploinsufficiency of protamine-1 or -2 causes infertility in mice.
Chunghee Cho,William D. Willis,Eugenia H. Goulding,Haesook Jung-Ha,Young-Chul Choi,Norman B. Hecht,Edward M. Eddy +6 more
TL;DR: It is found that a decrease in the amount of either protamine disrupts nuclear formation, processing of protamine-2 and normal sperm function, and that haploinsufficiency caused by a mutation in one allele of Prm1 or Prm2 prevents genetic transmission of both mutant and wild-type alleles.
Journal ArticleDOI
Protamine 2 Deficiency Leads to Sperm DNA Damage and Embryo Death in Mice
Chunghee Cho,Haesook Jung-Ha,William D. Willis,Eugenia H. Goulding,Paula Stein,Zhe Xu,Richard M. Schultz,Norman B. Hecht,Edward M. Eddy +8 more
TL;DR: It is suggested that development fails because of damage to paternal DNA and that PRM2 is crucial for maintaining the integrity of sperm chromatin.