N
Norman B. Hecht
Researcher at University of Pennsylvania
Publications - 161
Citations - 9001
Norman B. Hecht is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gene & Messenger RNA. The author has an hindex of 52, co-authored 161 publications receiving 8669 citations. Previous affiliations of Norman B. Hecht include University of Texas at Austin & Tufts University.
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Journal ArticleDOI
Haploinsufficiency of protamine-1 or -2 causes infertility in mice.
Chunghee Cho,William D. Willis,Eugenia H. Goulding,Haesook Jung-Ha,Young-Chul Choi,Norman B. Hecht,Edward M. Eddy +6 more
TL;DR: It is found that a decrease in the amount of either protamine disrupts nuclear formation, processing of protamine-2 and normal sperm function, and that haploinsufficiency caused by a mutation in one allele of Prm1 or Prm2 prevents genetic transmission of both mutant and wild-type alleles.
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Protamine 2 Deficiency Leads to Sperm DNA Damage and Embryo Death in Mice
Chunghee Cho,Haesook Jung-Ha,William D. Willis,Eugenia H. Goulding,Paula Stein,Zhe Xu,Richard M. Schultz,Norman B. Hecht,Edward M. Eddy +8 more
TL;DR: It is suggested that development fails because of damage to paternal DNA and that PRM2 is crucial for maintaining the integrity of sperm chromatin.
Journal ArticleDOI
Translational regulation and deadenylation of a protamine mRNA during spermiogenesis in the mouse
TL;DR: Results indicate that mRNA for one of the mouse protamines is stored as an untranslated RNP in round spermatids, and that it is partially deadenylated when it is translated in elongating sperMatids.
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MicroRNA Mirn122a Reduces Expression of the Posttranscriptionally Regulated Germ Cell Transition Protein 2 (Tnp2) Messenger RNA (mRNA) by mRNA Cleavage
TL;DR: 29 microRNAs from mouse testis that are differentially expressed as the prepubertal testis differentiates to the adult testis are reported and it is proposed that specific micro RNAs, such as Mirn122a, could be involved in the posttranscriptional regulation of mRNAs such as Tnp2 in the mammalian testis.
Journal ArticleDOI
Binding of a phosphoprotein to the 3' untranslated region of the mouse protamine 2 mRNA temporally represses its translation.
Yunhee Kim Kwon,Norman B. Hecht +1 more
TL;DR: It is proposed that a phosphorylated 18-kDa protein plays a primary role in repressing translation of mP2 mRNA by interaction with the highly conserved Y and H elements.