H
Hafedh Makni
Researcher at University of Sfax
Publications - 49
Citations - 1306
Hafedh Makni is an academic researcher from University of Sfax. The author has contributed to research in topics: Human leukocyte antigen & Population. The author has an hindex of 12, co-authored 49 publications receiving 1150 citations.
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Journal ArticleDOI
Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
Slaheddine Marrakchi,Philippe Guigue,Blair R. Renshaw,Anne Puel,Xue-Yuan Pei,Sylvie Fraitag,Jihen Zribi,Elodie Bal,Céline Cluzeau,Maya Chrabieh,Jennifer E. Towne,Jason Douangpanya,Christian Pons,Sourour Mansour,Valérie Serre,Hafedh Makni,Nadia Mahfoudh,Faiza Fakhfakh,Christine Bodemer,Josué Feingold,Smail Hadj-Rabia,Michel Favre,Emmanuelle Génin,Mourad Sahbatou,Arnold Munnich,Jean-Laurent Casanova,John E. Sims,Hamida Turki,Hervé Bachelez,Asma Smahi +29 more
TL;DR: Aberrant interleukin-36Ra structure and function lead to unregulated secretion of inflammatory cytokines and generalized pustular psoriasis.
Journal ArticleDOI
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis
L. Ben Mahmoud,H. Ghozzi,A. Kamoun,Ahmed Hakim,Hend Hachicha,Serria Hammami,Zouheir Sahnoun,N. Zalila,Hafedh Makni,Khaled Mounir Zeghal +9 more
TL;DR: The results suggest that the slow-acetylator status of NAT2 is risk factor for INH-induced hepatotoxicity and diplotypes, NAT2*5B/5B, NAT 2*6A/6A, 481T/T and 590A/A, are useful new biomarkers for predicting anti-TB drug-induced liver injuries.
Iconographies supplémentaires de l'article : Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis
L Ben Mahmoud,H. Ghozzi,A. Kamoun,Ahmed Hakim,Hend Hachicha,Serria Hammami,Zouheir Sahnoun,N. Zalila,Hafedh Makni,K. Zeghal +9 more
Journal ArticleDOI
Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles.
O. Abida,Mondher Zitouni,M. Kallel-Sellami,Nadia Mahfoudh,Arwa Kammoun,M. Ben Ayed,Abderrahmen Masmoudi,Mourad Mokni,B. Fezzaa,A. Ben Osman,M. R. Kammoun,Hamida Turki,Hafedh Makni,Danièle Gilbert,Pascal Joly,François Tron,S. Makni,Hatem Masmoudi +17 more
TL;DR: Pemphigus foliaceus is an autoimmune blistering skin disease that partly results from genetic factors, especially human leucocyte antigen (HLA) class II genes.
Journal ArticleDOI
Analysis of MHC genes in a Tunisian isolate with autoimmune thyroid diseases: implication of TNF -308 gene polymorphism.
Noura Bougacha-Elleuch,Ahmed Rebai,Mouna Mnif,Hafedh Makni,Mohamed Bellassouad,Jomaa Jouida,Mohamed Abid,A Hammadi +7 more
TL;DR: Examination of single and haplotypic genetic variation across the major histocompatibility complex in a Tunisian isolate with a high prevalence of AITDs confirmed the involvement of the TNF -308 gene polymorphism in AITD pathogenesis.