Haiou Yang

TL;DR: It is demonstrated that CAFs secrete exosomal miR-522 to inhibit ferroptosis in cancer cells by targeting ALOX15 and blocking lipid-ROS accumulation, which results in decreased chemo-sensitivity.

TL;DR: It is proposed that EGFR-containing exosomes derived from cancer cells could favour the development of a liver-like microenvironment promoting liver-specific metastasis and be incorporated on the plasma membrane of liver stromal cells.

TL;DR: In vitro and in vivo studies showed that exosomes from oxaliplatin‐resistant cells delivered ciRS‐122 to sensitive cells, thereby promoting glycolysis and drug resistance through miR‐122 sponging and PKM2 upregulation and establishing a foundation for future clinical applications in drug‐resistant CRC.

TL;DR: It is shown thatcircRNAs in plasma exosomes have specific expression features in gastric cancer (GC), and ciRS‐133 is linked with the browning of white adipose tissue (WAT) in GC patients, and exosome‐delivered circRNAs are involved in WAT browning and play a key role in cancer‐associated cachexia.

TL;DR: It is demonstrated that exosomes delivered miR-130a from gastric cancer cells into vascular cells to promote angiogenesis and tumor growth by targeting c-MYB both in vivo and in–vitro.