H
Hajime Mizuno
Researcher at University of Shizuoka
Publications - 62
Citations - 1331
Hajime Mizuno is an academic researcher from University of Shizuoka. The author has contributed to research in topics: Mass spectrometry & Chemistry. The author has an hindex of 19, co-authored 54 publications receiving 1021 citations. Previous affiliations of Hajime Mizuno include RIKEN Quantitative Biology Center & Hiroshima University.
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Journal ArticleDOI
Direct metabolomics for plant cells by live single-cell mass spectrometry
Takashi Fujii,Shuichi Matsuda,Mónica Lorenzo Tejedor,Tsuyoshi Esaki,Iwao Sakane,Hajime Mizuno,Naohiro Tsuyama,Tsutomu Masujima +7 more
TL;DR: Live single-cell mass spectrometry (live MS) provides a mass spectrum that shows thousands of metabolite peaks from a single live plant cell within minutes and can be acquired in 10 min.
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Live single‐cell video‐mass spectrometry for cellular and subcellular molecular detection and cell classification
TL;DR: The molecular content from the cytoplasm of a live, single mammalian cell and its organelle were trapped with a nano-electrospray ionization tip acting as a micropipette under a video microscope, and hundreds of small molecular peaks were detected by direct nano-ESI mass spectrometry (MS).
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Cell-specific localization of alkaloids in Catharanthus roseus stem tissue measured with Imaging MS and Single-cell MS.
Kotaro Yamamoto,Katsutoshi Takahashi,Hajime Mizuno,Aya Anegawa,Kimitsune Ishizaki,Hidehiro Fukaki,Miwa Ohnishi,Mami Yamazaki,Tsutomu Masujima,Tetsuro Mimura +9 more
TL;DR: The present study showed, using both Imaging mass spectrometry (MS) and Single-cell MS, that many kinds of TIA intermediates, including catharanthine and serpentine, were accumulated in idioblast and laticifer cells of C. roseus stem tissue.
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In Situ Molecular Analysis of Plant Tissues by Live Single-Cell Mass Spectrometry
TL;DR: A rapid, direct molecular analysis of live, single plant cells viewed under a video microscope in their natural environment and will allow different cell types and stages from different sites in the plant to be compared with morphological observations is reported.
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Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry
Takahiro Takayama,Haruhito Tsutsui,Ippei Shimizu,Tatsuya Toyama,Nobuyasu Yoshimoto,Yumi Endo,Koichi Inoue,Kenichiro Todoroki,Jun Zhe Min,Hajime Mizuno,Toshimasa Toyo'oka +10 more
TL;DR: The discrimination equation appears to be useful for the diagnosis of breast cancer patients and may be adopted as an index of the health status after the surgical treatment.